Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches.
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches.
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作者：
Park MH;Hong JT
核因子-κB（NF-κB）是一种转录因子，在免疫应答、炎症、细胞生长和存活以及发育等多种生物学过程中起着至关重要的作用。NF-κB对人类健康至关重要，并且异常的NF-κB活化有助于各种自身免疫性、炎性和恶性疾病的发展，包括类风湿性关节炎、动脉粥样硬化、炎性肠病、多发性硬化和恶性肿瘤。因此，抑制NF-κB信号传导在癌症和炎性疾病中具有潜在的治疗应用。
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors. Thus, inhibiting NF-κB signaling has potential therapeutic applications in cancer and inflammatory diseases.