Rationale, methods and baseline demographics of the Bhaktapur Glaucoma Study
Rationale, methods and baseline demographics of the Bhaktapur Glaucoma Study
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DOI：
10.1111/j.1442-9071.2010.02429.x
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发表时间：
2011-03-01
影响因子：
4
通讯作者：
van Rens, Ger
中科院分区：
文献类型：
--
作者：
Thapa, Suman S.;Rana, Pooja P.;van Rens, Ger
P>背景：描述一项基于人群的研究的方法和基线数据，该研究旨在确定青光眼的患病率并研究尼泊尔人群青光眼发生的危险因素。设计：基于人群的横断面研究参与者：居住在巴克塔普尔地区的 40 岁及以上受试者。患者和方法：功效计算表明需要 4758 名样本量。从尼泊尔巴克塔普尔地区的 2 个市镇和 16 个村庄发展委员会中随机抽取了 30 个集群。在选定的聚集区进行了挨家挨户的人口普查，以确定 40 岁及以上的公民。收集了人口统计详细信息，并进行了有关白内障和青光眼意识的结构化访谈。所有符合资格标准的个人都被招募并转诊至加德满都的蒂尔甘加眼科研究所进行详细的临床检查，包括青光眼诊断程序。采集外周血样本，以便于进一步进行基因分析。主要指标：青光眼患病率、危险因素和基因筛查。结果：共入选4800人。参与者的平均年龄为 55.4 +/- 12.3 岁（范围：40-99），其中 51.8% 为女性。总的来说，我们的队列中 64.8% 的人年龄不到 59 岁，60.5% 是文盲。在各个民族中，69.7%属于尼瓦尔族。结论：这项研究将确定青光眼的患病率，并加深对该地区青光眼发生风险因素的了解。
P>Background:To describe the methodology and baseline data of a population-based study designed to determine the prevalence of glaucoma and to study the risk factors for glaucoma development in a Nepali population.Design:Population-based cross-sectional studyParticipants:Subjects 40 years and above residing in Bhaktapur District.Patients and Methods:Power calculations suggest that a sample size of 4758 is required. Thirty clusters were randomly selected from the 2 municipalities and 16 Village Development Committees of Bhaktapur District in Nepal. A door-to-door census was conducted in the selected clusters to identify citizens 40 years of age and older. Demographic details were collected and a structured interview, regarding awareness for cataract and glaucoma was taken. All individuals fulfilling the eligibility criteria were recruited and referred to the Tilganga Institute of Ophthalmology in Kathmandu for a detailed clinical examination including glaucoma diagnostic procedures. Peripheral blood samples were taken to facilitate future genetic analysis.Main Outcome Measures:Prevalence of glaucoma, risk factors and genetic screening.Results:A total of 4800 people were selected. The mean age of participants was 55.4 +/- 12.3 years (range: 40-99) and 51.8% were female. In total, 64.8% of our cohort was aged less than 59 years and 60.5% were illiterate. Among the various ethnic races, 69.7% belonged to the Newar ethnic group.Conclusion:This study will determine the prevalence of glaucoma and allow for an increased understanding of the risk factors for glaucoma development in this region.