The parahippocampal gyrus as a neural marker of early remission in first-episode psychosis: a voxel-based morphometry study.
The parahippocampal gyrus as a neural marker of early remission in first-episode psychosis: a voxel-based morphometry study.
复制标题
DOI：
10.3371/csrp.4.4.2
复制
发表时间：
2011-01-01
影响因子：
--
通讯作者：
Lepage, Martin
中科院分区：
文献类型：
--
作者：
Bodnar, Michael;Harvey, Philippe-Olivier;Lepage, Martin
简介：精神病性障碍的预后是异质性的，长期临床预后不良与内囊容积减少和心室容积增加等标志物相关。没有以前的研究已经检查了神经影像学标记物在早期resultation.METHODS：本神经影像学研究包括68个以前未经治疗的精神病（FEP）的第一次发作的患者，其中28个达到缓解和40没有经过6个月的治疗，和42名健康对照。使用基于体素的形态测量（VBM），我们着手确定是否可以确定特定的神经相关性FEP患者没有达到缓解在一个专门的早期干预service.Results：Nonremitted患者有显着较低的灰质浓度（GMC）在海马旁回双边相比，缓解患者。利用海马旁GMC的分类模型正确分类缓解状态的时间为79%，占方差的56%。此外，左侧（r=-0.35，p =0.004）和右侧（r=-0.47，p =0.004）GMC
INTRODUCTION: Outcome from psychotic disorders is heterogeneous with poor long-term clinical outcome associated with such markers as decreased internal capsule volume and increased ventricular volumes. No previous study has examined neuroimaging markers in relation to early remission.METHODS: This neuroimaging study included 68 previously untreated first episode of psychosis (FEP) patients, of whom 28 achieved remission and 40 did not after six months of treatment, and 42 healthy controls. Using voxel-based morphometry (VBM), we set out to determine if specific neural correlates could be identified in FEP patients not achieving remission in a specialized early-intervention service.RESULTS: Nonremitted patients had significant lower grey matter concentration (GMC) in the parahippocampal gyrus bilaterally compared to remitted patients. A classification model utilizing parahippocampal GMC correctly classified remission status 79% of the time and accounted for 56% of the variance. Moreover, GMC on the left (r=-0.35, p=0.004) and right (r=-0.47, p