Association Between Polymorphisms of ADRBK1 Gene and Plasma Renin Activity in Hypertensive Patients: A Case-Control Study.
Association Between Polymorphisms of ADRBK1 Gene and Plasma Renin Activity in Hypertensive Patients: A Case-Control Study.
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高血压患者 ADRBK1 基因多态性与血浆肾素活性的关联：病例对照研究
DOI：
10.12659/msm.896579
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发表时间：
2016-08-24
期刊：
影响因子：
--
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Li Y;Li N;Yao X;Heizati M;Zhang D;Zhu Q;Chang G;Zhang X
肾素是RAS级联的第一步，其是盐体积稳态的主要调节剂。肾上腺素能β受体激酶1（Adrenergic beta receptor kinase 1，ADRBK 1）通过上皮Na+通道（epithelial Na+ channel，ENaC）调节血压，在肾集合管Na+重吸收中起重要作用。本研究旨在探讨ADRBK 1基因多态性与高血压患者血浆肾素活性（PRA）的关系。我们招募了1831名高血压和422名血压正常的汉族受试者。采用放射免疫法测定坐位PRA（ng/mL/h）。采用PRA四分位数将高血压患者分为4类。通过TaqMan聚合酶链反应鉴定ADRBK 1基因（rs 1894111、rs 4930416、rs7127431、rs 12286664和rs3730147）的单核苷酸多态性（SNP）。高血压组与对照组比较，rs 1894111基因型和等位基因分布差异有统计学意义（P<0.05）。高血压组rs 1894111位点优势模式（CC vs. CT+TT）的分布低于对照组（P<0.05）。根据PRA四分位数将受试者分为4个亚组; rs 1894111的显性模型（CC vs. CT+TT）在四分位数1组（PRA最低组）中显著低于对照组（P<0. 05）。Logistic回归分析显示rs 1894111的优势模式（CC vs. CT+TT）在高血压组中差异有统计学意义（OR=1.590，95%CI=1.022-2.474，P<0.05），尤其是在第1组（OR=1.845，95%CI=1.119-3.042，P<0.05），而在第4组中差异无统计学意义。ADRBK 1基因rs 1894111多态性的显性模式（CC vs. CT+TT）可能与中国汉族人低肾素高血压相关。
Renin is the first step of the RAS cascade, which is a major regulator of salt-volume homeostasis. Adrenergic beta receptor kinase 1 (ADRBK1) plays important roles in regulating blood pressure via the epithelial Na+ channel (ENaC), which plays an important role in Na+ reabsorption in the renal collecting duct. The present case-control study was designed to investigate the potential relationship between polymorphisms of ADRBK1 and plasma renin activity (PRA) in hypertension. We recruited 1831 hypertensive and 422 normotensive Han Chinese subjects. Sitting PRA (ng/mL/h) was measured using radioimmunoassay method. Hypertensive patients were classified into 4 renin categories via PRA quartile. Single-nucleotide polymorphisms (SNPs) of the ADRBK1 gene (rs1894111, rs4930416, rs7127431, rs12286664, and rs3730147) were identified via TaqMan polymerase chain reaction. Comparison of the hypertensive group and the control group showed significant differences in distribution of genotypes and alleles of rs1894111 (P<0.05). Moreover, distribution of the dominant model (CC vs. CT+TT) in rs1894111 was lower in the hypertensive group than in the control group (P<0.05). Subjects were classified into 4 subgroups based on PRA quartile; the dominant model (CC vs. CT+TT) of rs1894111 was significantly lower in the quartile 1 group (the group with the lowest PRA) than in the control group (P<0.05). Logistic regression analysis demonstrated that the dominant model (CC vs. CT+TT) of rs1894111 was significantly different in the hypertensive group (OR=1.590, 95%CI=1.022–2.474, P<0.05), particularly in the quartile 1 group (OR=1.845, 95%CI=1.119–3.042, P<0.05), but not in the quartile 4 group. The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese.
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影响因子：
3.7
作者：
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影响因子：
2.7
作者：
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影响因子：
3.2
作者：
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影响因子：
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作者：
Sim, John J.;Bhandari, Simran K.;Laragh, John H.
通讯作者：
Laragh, John H.
DOI：
10.1161/hypertensionaha.108.125955
发表时间：
2009-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Cohn HI;Xi Y;Pesant S;Harris DM;Hyslop T;Falkner B;Eckhart AD
通讯作者：
Eckhart AD