Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men
Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men
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DOI：
10.1210/clinem/dgab037
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发表时间：
2021-01-23
影响因子：
5.8
通讯作者：
Watada, Hirotaka
中科院分区：
文献类型：
--
作者：
Kiya, Mai;Tamura, Yoshifumi;Watada, Hirotaka
内容：脂肪组织功能障碍的特征在于脂联素（AN）水平降低和脂肪组织胰岛素敏感性（ATIS）受损，并与代谢紊乱相关。虽然亚洲人在不肥胖的情况下容易发生代谢性疾病，但目前尚不清楚AN水平降低和ATIS受损如何影响非肥胖亚洲人的代谢异常。设计和设置：为了研究AN水平降低、ATIS受损和代谢异常之间的关系，我们对94名体重指数低于25 kg/m2的日本男性进行了研究。我们将受试者分为4组的基础上，他们的中位数AN水平和ATIS，后者计算为胰岛素介导的抑制程度的游离脂肪酸在高胰岛素-正葡萄糖钳夹，并比较在4 groups.Results的代谢参数：高ATIS/高AN组（n = 29）显示类似的人体测量数据的高ATIS/低AN组（n = 18）。相比之下，低ATIS/高AN（n = 18）和低ATIS/低AN（n = 29）组显示出比高ATIS组显著更低的肌肉胰岛素敏感性。Low-ATIS/Low-AN组肝内脂质水平显著高于High-ATIS组。此外，低ATIS/低AN组有一个显着较高的空腹血清甘油三酯水平和显着较低的高密度脂蛋白胆固醇水平比其他3 groups.Conclusions：在非肥胖的日本男性高ATIS，AN水平与代谢特征无关。另一方面，ATIS低的受试者显示肌肉胰岛素敏感性降低，AN水平降低的受试者表现出以脂肪肝和血脂异常为代表的多种代谢异常。
Context: Adipose tissue dysfunction is characterized by decreased adiponectin (AN) levels and impaired adipose tissue insulin sensitivity (ATIS) and is associated with metabolic disorders. While Asians readily develop metabolic disease without obesity, it remains unclear how decreased AN level and impaired ATIS affect metabolic abnormalities in nonobese Asians.Design and Setting: To investigate the relationships between decreased AN level, impaired ATIS, and metabolic abnormalities, we studied 94 Japanese men whose body mass index was less than 25 kg/m(2). We divided the subjects into 4 groups based on their median AN level and ATIS, the latter calculated as the degree of insulin-mediated suppression of free fatty acids during hyperinsulinemic euglycemic clamp, and compared the metabolic parameters in the 4 groups.Results: The High-ATIS/High-AN group (n = 29) showed similar anthropometric data to the High-ATIS/Low-AN group (n = 18). In contrast, both the Low-ATIS/High-AN (n = 18) and Low-ATIS/Low-AN (n = 29) groups showed significantly lower muscle insulin sensitivity than the High-ATIS groups. The intrahepatic lipid level in the Low-ATIS/Low-AN group was significantly higher than that in the High-ATIS groups. In addition, the Low-ATIS/Low-AN group had a significantly higher fasting serum triglyceride level and significantly lower high-density lipoprotein cholesterol level than the other 3 groups.Conclusions: In nonobese Japanese men with high ATIS, the AN level was not associated with metabolic characteristics. On the other hand, subjects with low ATIS showed reduced muscle insulin sensitivity, and those with a decreased AN level demonstrated multiple metabolic abnormalities, represented by fatty liver and dyslipidemia.