Respiratory illness and acute flaccid myelitis in the Tokai district in 2018
Respiratory illness and acute flaccid myelitis in the Tokai district in 2018
复制标题
2018年东海地区呼吸系统疾病和急性弛缓性脊髓炎
DOI：
10.1111/ped.14128
复制
发表时间：
2020
影响因子：
1.4
通讯作者：
Takahashi Yoshiyuki
中科院分区：
文献类型：
--
作者：
Okumura Akihisa;Numoto Shingo;Iwayama Hideyuki;Kurahashi Hirokazu;Natsume Jun;Saitoh Shinji;Yoshikawa Tetsushi;Fukao Toshiyuki;Hirayama Masahiro;Takahashi Yoshiyuki
急性弛缓性肌麻痹症的爆发与2015年日本严重呼吸道疾病的爆发在时间上相关。我们假设2018年秋季因严重呼吸道疾病住院儿童的增加也可能与急性弛缓性肌麻痹的增加有关。方法我们使用问卷调查探讨了2016年至2018年秋季呼吸道疾病爆发与急性弛缓性肌麻痹之间的时间相关性。一份问卷调查了每月患有急性弛缓性肌麻痹、格林-巴利综合征和其他急性弛缓性麻痹的儿童人数。另一份问卷调查了每月因喘息相关呼吸系统疾病住院的儿童人数。使用Pearson相关性检验分析了急性弛缓性肌麻痹儿童和呼吸系统疾病儿童的月数之间的相关性。ResultsAlthough the number of patients hospitalized with respiratory diseases does not correlate with those admitted with myeloid，7-12岁和13岁儿童人数增加，19年需要重症监护病房入院时间与急性弛缓性肌无力的爆发时间相关。与一簇急性弛缓性肌麻痹有关由于呼吸道疾病而进入重症监护室的人数增加可能是预期急性弛缓性肌无力发生的线索。
BackgroundAn outbreak of acute flaccid myelitis was chronologically correlated with an outbreak of severe respiratory illness in Japan in 2015. We hypothesized that increases in children hospitalized with severe respiratory illnesses might also be associated with increase in acute flaccid myelitis in autumn 2018.MethodsWe explored the temporal correlations between respiratory illness outbreaks and acute flaccid myelitis during autumn season between 2016 and 2018 using questionnaire surveys. One questionnaire explored the monthly numbers of children with acute flaccid myelitis, Guillain–Barré syndrome, and other acute flaccid paralyses. The other questionnaire explored the monthly numbers of children hospitalized with respiratory illnesses associated with wheezing. A correlation between the monthly numbers of children with acute flaccid myelitis and those with respiratory illness was analyzed using the Pearson correlation test.ResultsAlthough the number of patients hospitalized with respiratory illness did not correlate with the number of those admitted with myelitis, increases in children aged 7–12 and 13–19 years requiring intensive care unit admission correlated temporally with an outbreak of acute flaccid myelitis.ConclusionsAn increase in intensive care unit admissions to treat respiratory disease occurred in association with a cluster of acute flaccid myelitis. An increase in the number of intensive care unit admissions due to respiratory illness may be a clue to expect the occurrence of acute flaccid myelitis.