Course of indicators of thrombin activity in the early phase of acute myocardial infarction: effect of fibrinolytic therapy and acute percutaneous coronary angioplasty
Course of indicators of thrombin activity in the early phase of acute myocardial infarction: effect of fibrinolytic therapy and acute percutaneous coronary angioplasty
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急性心肌梗死早期凝血酶活性指标变化过程：溶纤治疗和急性经皮冠状动脉成形术的效果
DOI：
10.1055/s-0037-1613611
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发表时间：
2003
影响因子：
6.7
通讯作者：
M. Borggrefe
中科院分区：
文献类型：
--
作者：
C. Dempfle;J. Kaden;K. Haase;M. Borggrefe
我们评估了检测急性心肌梗死患者体内凝血酶活性的检测系统。这项研究包括31名连续接受纤溶治疗(Flt)或急性PTCA治疗的急性心肌梗死患者。分别于入院时、入院时、入院后30min、1h、3h、6h、12h、24、48h抽血测定凝血酶活性，包括纤维蛋白肽A-EL ISA，一种新的乳胶增强型光度免疫分析方法，用于检测可溶性纤维蛋白复合体、纤维蛋白单体抗原、D-二聚体抗原和可溶性血小板膜糖蛋白V，后者通过凝血酶裂解从血小板表面释放出来。可溶性纤维蛋白与纤维蛋白肽A高度相关，与D-二聚体抗原无相关性，提示该参数可用于监测急性心肌梗死患者体内凝血酶活性。纤维蛋白单体抗原和D-二聚体抗原受Flt的影响，表明与纤维蛋白的蛋白水解物片段发生交叉反应。可溶性糖蛋白V无明显变化。结果表明，无论对Flt或急性PTCA的初步治疗决定如何，这种新的可溶性纤维蛋白测定方法似乎是一种很有前途的方法，可用于测量急性心肌梗死患者体内纤维蛋白的形成。
Summary We evaluated assay systems for detection of in vivo thrombin activity in patients with acute myocardial infarction. The study included 31 consecutive patients with acute myocardial infarction treated either with fibrinolytic therapy (FLT), or acute PTCA. Blood samples were drawn at admission, after 30 min, 1 h, 3 h, 6 h, 12 h, 24, and 48 h. Assays related to the enzymatic action of thrombin included fibrinopeptide A ELISA, a novel latex-enhanced photometric immunoassay for soluble fibrin complexes, fibrin monomer antigen, D-dimer antigen, and soluble platelet glycoprotein V, which is released from the platelet surface by thrombin cleavage. The soluble fibrin assay displayed a high degree of correlation with fibrinopeptide A, and no correlation with D-dimer antigen, indicating that this parameter allows monitoring of in vivo thrombin activity in patients with acute myocardial infarction. Fibrin monomer antigen, and D-dimer antigen, were influenced by FLT, indicating cross-reactivity with proteolytic fragments of fibrin. No significant changes in soluble glycoprotein V were observed. The results show that the novel soluble fibrin assay appears to be a promising method for measurement of in vivo fibrin formation in patients with acute myocardial infarction, irrespective of the primary treatment decision for FLT or acute PTCA.
心肌梗塞患者血浆中血小板因子 IV 缺乏升高。
影响因子：
24
作者：
Jaffe,AS;Lee,RG;Perez,JE;Geltman,EM;Wilner,GD;Sobel,BE
通讯作者：
Sobel,BE
急性心肌梗死患者溶栓和联合肝素治疗期间凝血酶的生成和活性。
影响因子：
24
作者：
Merlini,PA;Bauer,KA;Oltrona,L;Ardissino,D;Spinola,A;Cattaneo,M;Broccolino,M;Mannucci,PM;Rosenberg,RD
通讯作者：
Rosenberg,RD