Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion
Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion
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DOI：
10.1016/j.brainres.2008.03.040
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发表时间：
2008-07-11
期刊：
影响因子：
2.9
通讯作者：
Ichikawa, Hiroyuki
中科院分区：
文献类型：
--
作者：
Omori, Megumi;Yokoyama, Masataka;Ichikawa, Hiroyuki
我们研究了L5脊神经结扎（SNL）诱导的神经病变大鼠后爪注射乙酸后疼痛行为的变化。我们还研究了L5 SNL大鼠背根神经节（DRG）酸敏感离子通道3（ASIC 3）的免疫反应性。SNL后2周，SNL组对机械刺激的退缩阈值显著低于假手术组（n=9/组，P 1200 mm（2））。
We investigated changes in pain behavior after injection of acetic acid in the hindpaws of rats with L5 spinal nerve ligation (SNL)-induced neuropathy. We also examined immunoreactivity for acid-sensing ion channel 3 (ASIC3) in the dorsal root ganglion (DRG) of rats with L5 SNL. Two weeks after SNL, the withdrawal threshold to a mechanical stimulus was significantly lower in the SNL group than in the sham-operated group (n=9 per group, P 1200 mm(2)) ASIC3-ir neurons in the ipsilateral L4 DRG significantly increased after L5 SNL (P