Cytokines in Human Milk: Properties and Potential Effects upon the Mammary Gland and the Neonate
Cytokines in Human Milk: Properties and Potential Effects upon the Mammary Gland and the Neonate
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DOI：
10.1007/bf02018078
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发表时间：
1996-07-01
影响因子：
2.5
通讯作者：
Schmalstieg, Frank C.
中科院分区：
文献类型：
--
作者：
Goldman, Armond S.;Chheda, Sadhana;Schmalstieg, Frank C.
对母乳喂养和非母乳喂养婴儿的流行病学和免疫学研究以及对母乳中某些生物活性的研究导致了母乳中免疫调节剂的鉴定。其中包括细胞因子白细胞介素 1 β (IL-1 β)(3)； IL-6、IL-8、IL-10、粒细胞集落刺激因子、巨噬细胞集落刺激因子 (M-CSF)、肿瘤坏死因子-α、干扰素-γ、上皮生长因子 (EGF)、转化生长因子-α (TGF-α) 和 TGF-β 2。干扰素-γ 可能源自乳汁中的 T 细胞； EGF、TGF-α、TGF-β、M-CSF、IL-6 和 IL-8 可由乳腺上皮产生。根据其已知的功能，我们假设细胞因子影响乳腺和新生儿的发育和免疫功能。这些体内功能仍有待未来的研究来确定。
Epidemiologic and immunologic studies of breastfed and nonbreastfed infants and investigations of certain biologic activities in human milk led to the identification of immunomodulating agents in human milk. Among them were the cytokines interleukin-1 beta (IL-1 beta)(3); IL-6, lL-8, IL-10, granulocyte-colony stimulating factor, macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha, interferon-gamma, epithelial growth factor (EGF), transforming growth factor-alpha (TGF-alpha), and TGF-beta 2. Interferon-gamma may originate from T cells in milk; EGF, TGF-alpha, TGF-beta, M-CSF, IL-6, and IL-8 may be produced by mammary gland epithelium. Based upon their known functions, we hypothesize that cytokines influence the development and immunologic function of the mammary gland and the neonate. Those in vivo functions remain to be defined by future investigations.