Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying blaKPC-2, blaDHA-1, qnrB4, and armA
Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying blaKPC-2, blaDHA-1, qnrB4, and armA
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DOI：
10.1128/aac.00137-10
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发表时间：
2010-09-01
影响因子：
4.9
通讯作者：
Yu, Yunsong
中科院分区：
文献类型：
--
作者：
Jiang, Yan;Yu, Dongliang;Yu, Yunsong
对肺炎克雷伯菌多重耐药质粒pKP 048进行全序列测定。该质粒携带几个重要的耐药决定簇，如bla（KPC-2）、bla（DHA-1）、qnrB 4和阿尔马，它们分别赋予对碳青霉烯类、头孢菌素类、氟喹诺酮类和氨基糖苷类的耐药性。对151，188-bp序列的分析显示了163个可能的基因，其中108个被分配了复制、稳定遗传、抗生素抗性、移动的元件、接合转移和限制修饰系统等功能，显示了质粒的强系统发育嵌合性和可塑性。
The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced. This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively. Analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 of which were assigned functions such as replication, stable inheritance, antibiotic resistance, a mobile element, conjugal transfer, and a restriction-modification system, showing the strong phylogenetic mosaicism and plasticity of the plasmid.