Pulse-wave velocity measured in one heartbeat using MR tagging
Pulse-wave velocity measured in one heartbeat using MR tagging
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DOI：
10.1002/mrm.10177
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发表时间：
2002-07-01
影响因子：
3.3
通讯作者：
Wood, ML
中科院分区：
文献类型：
--
作者：
Macgowan, CK;Henkelman, RM;Wood, ML
介绍了一种测量单次心跳中主动脉脉搏波速度（PWV）的无创方法。该方法以正弦曲线方式标记血管内的血柱，并在标签移动时快速获取一系列标签的 ID 投影（实际上，以 4 毫秒的间隔进行 64 个投影）。根据这些投影，可以测量血液沿血管不同位置的相对运动。 PWV 是通过将血流数学模型拟合到标签轨迹来获得的。使用乳胶和聚氨酯管在脉动流模型中对该方法进行了测试。在这些管中测得的 PWV 分别为（平均值 +/- 标准偏差）4.4 +/- 0.5 m/s 和 2.3 +/- 0.2 m/s。根据 PWV 计算每根管的扩张性（乳胶 = (7 +/- 2) 10(-3) mm Hg-1，poly. = (25 +/- 4) 10(-3) mm Hg-1），并发现与基于管面积随压力变化的扩张性测量值在误差范围内一致（乳胶 = (6.3 +/- 0.3) 10(-3) mm Hg-1，poly. = (27 +/- 1) 10(-3) 毫米汞柱-1)。为了测试其可行性，对四名正常志愿者进行了 PWV 测量。测得的 PWV 值为 3.9 +/- 0.8 m/s、3.6 +/- 0.9 m/s、3.9 +/- 0.5 m/s 和 5.3 +/- 0.8 m/s。通过获取每次心跳的独立 PWV 测量，该方法似乎可以避免心律失常和触发变异引起的误差。 (C) 2002 Wiley-Liss, Inc.
A noninvasive method for measuring the aortic pulse-wave velocity (PWV) in a single heartbeat is introduced. The method sinusoidally tags a column of blood within the vessel, and rapidly acquires a series of I D projections of the tags as they move (in practice, 64 projections at 4-ms intervals). From these projections, the relative motion of blood at different positions along the vessel is measured. The PWV is obtained by fitting a mathematical model of blood flow to the tag trajectories. Tests of this method in a pulsatile flow phantom are presented using latex and polyurethane tubes. The PWV measured in these tubes was (mean +/- standard deviation) 4.4 +/- 0.5 m/s and 2.3 +/- 0.2 m/s, respectively. The distensibility of each tube was calculated from the PWV (latex = (7 +/- 2) 10(-3) mm Hg-1, poly. = (25 +/- 4) 10(-3) mm Hg-1) and found to agree within error with distensibility measurements based on the change of tube area with pressure (latex = (6.3 +/- 0.3) 10(-3) mm Hg-1, poly. = (27 +/- 1) 10(-3) mm Hg-1). To test its feasibility, the PWV measurement was applied to four normal volunteers. The measured PWV values were 3.9 +/- 0.8 m/s, 3.6 +/- 0.9 m/s, 3.9 +/- 0.5 m/s, and 5.3 +/- 0.8 m/s. By acquiring an independent PWV measurement each heartbeat, errors introduced by arrhythmia and trigger variability appear to be avoided with this method. (C) 2002 Wiley-Liss, Inc.