Beta-adrenergic responsiveness of choroidal vasculature.
Beta-adrenergic responsiveness of choroidal vasculature.
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脉络膜血管系统的β-肾上腺素能反应性。
DOI：
10.1016/s0161-6420(91)32216-4
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发表时间：
1991
期刊：
影响因子：
13.7
通讯作者：
Anderson,DR
中科院分区：
文献类型：
--
作者：
Grajewski,AL;Ferrari-Dileo,G;Feuer,WJ;Anderson,DR
作者使用体外结合方法和放射自显影术，在白化病兔中发现脉络膜血管特异性结合碘125氰基吲哚酚（β-肾上腺素能受体的非选择性阻断剂）。在人体中，通过马来酸噻吗洛尔（一种非选择性β-肾上腺素能受体阻滞剂）全身给药后显示脉络膜血管张力增加，证实了脉络膜血管中存在β-肾上腺素能受体。马来酸噻吗洛尔局部给药可降低眼内压，但未达到足以对血管张力产生可测量影响的量的脉络膜受体。
Using in vitro binding methods and autoradiographs, the authors showed that choroidal vessels specifically bind iodine 125 cyanopindolol, a nonselective blocker of beta-adrenergic receptors, in albino rabbits. In humans, the presence of beta-adrenergic receptors in choroidal vessels was confirmed by showing an increased choroidal vascular tone after systemic administration of timolol maleate, a nonselective beta-adrenergic blocker. Topically administered timolol maleate lowered the intraocular pressure but did not reach the choroidal receptors in sufficient quantity to produce a measurable effect on vascular tone.