Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities
Synthesis of 2-aziridinyl phosphonates by modified Gabriel-Cromwell reaction and their antibacterial activities
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DOI：
10.1016/j.ejmech.2011.03.037
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发表时间：
2011-06-01
影响因子：
6.7
通讯作者：
Budak, Songul
中科院分区：
文献类型：
--
作者：
Dogan, Ozdemir;Babiz, Hakan;Budak, Songul
利用Gabriel-Cromwell反应及其改进的方法合成了一系列新的氮丙啶基膦酸酯（4a-g），其结构经高分辨质谱、红外光谱和核磁共振谱确证。对所有化合物进行了抗菌活性筛选。它们均显示出与氨苄青霉素和链霉素相当的中度至良好的生长抑制活性。(C)2011年Elsevier Masson SAS。All rights reserved.
A set of new aziridinyl phosphonates (4a-g) were synthesized by using the Gabriel-Cromwell reaction and its modified version developed in this study and their structures confirmed by HRMS, IR. and NMR spectra. All the compounds were screened for their antibacterial activity. They all showed comparable moderate to good growth inhibitory activity in reference to ampicillin and streptomycin. (C) 2011 Elsevier Masson SAS. All rights reserved.