The role of hepatokines in NAFLD.
The role of hepatokines in NAFLD.
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DOI：
10.1016/j.cmet.2023.01.006
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发表时间：
2023-02-07
期刊：
影响因子：
29
通讯作者：
White, Morris F.
中科院分区：
文献类型：
--
作者：
Stefan, Norbert;Schick, Fritz;Birkenfeld, Andreas L.;Haering, Hans-Ulrich;White, Morris F.
非酒精性脂肪性肝病(NAFLD)不仅是胰岛素抵抗的结果，也是胰岛素抵抗和重大非传染性疾病(NCDs)的重要原因。NAFLD与内脏肥胖的密切关系掩盖了内脏肥胖性脂肪肝作为胰岛素抵抗和非传染性疾病的主要发病机制的作用。为了克服这一局限，类似于脂肪因子的概念，我们在2008年引入了术语肝因子来描述胎球蛋白-A在新陈代谢中的作用。从那时起，还测试了其他几种肝素对新陈代谢的影响。在这里，我们解决了非酒精性脂肪肝患者肝素调节失调的问题。然后，我们通过肝细胞因子相关的器官串扰，讨论了与NAFLD相关的心脏代谢疾病的病理生理机制。最后，我们建议如何将主要肝因子和脂肪因子的测定用于NAFLD和内脏肥胖的胰岛素抵抗的病理机制聚集性，以便更好地在临床实践中实施精确医学。
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance, but it is also an important cause of insulin resistance and major non-communicable diseases (NCDs). The close relationship of NAFLD with visceral obesity obscures the role of fatty liver from visceral adiposity as the main pathomechanism of insulin resistance and NCDs. To overcome this limitation, in analogy to the concept of adipokines, in 2008 we introduced the term hepatokines to describe the role of fetuin-A in metabolism. Since then, several other hepatokines were tested for their effects on metabolism. Here we address the dysregulation of hepatokines in people with NAFLD. Then, we discuss pathophysiological mechanisms of cardiometabolic diseases specifically related to NAFLD by focusing on hepatokine-related organ crosstalk. Finally, we propose how the determination of major hepatokines and adipokines can be used for pathomechanism-based clustering of insulin resistance in NAFLD and visceral obesity to better implement precision medicine in clinical practice.
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