Pregnancy alters the hemodynamic responses to cocaine in the rat.
Pregnancy alters the hemodynamic responses to cocaine in the rat.
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怀孕改变了大鼠对可卡因的血流动力学反应。
DOI：
10.1159/000457467
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
MillerJr,ED
中科院分区：
文献类型：
--
作者：
Morishima,HO;Cooper,TB;Hara,T;MillerJr,ED
为了验证我们的假设，即怀孕期间可卡因的血流动力学反应可能会改变，我们将可卡因(0.33 mg/kg/min)静脉注入到长期插管的怀孕和未怀孕的雌性大鼠中。测定心输出量和局部血流量，测定血浆和组织中可卡因浓度及血浆胆碱酯酶活性。将妊娠组与非妊娠组的结果进行比较。可卡因导致怀孕大鼠心率显著减慢，同时心输出量下降，大脑、心肌和胎盘血流量减少。妊娠动物的血浆可卡因浓度低于非妊娠动物，但两组动物的组织浓度相似。这些结果表明，怀孕增强了心血管对亚毒性剂量可卡因的反应。胎儿和母亲的血浆浓度比为0.28时，几乎没有可卡因的胎盘转移。
To test our hypotheses that the hemodynamic response to cocaine may be altered during pregnancy, cocaine (0.33 mg/kg/min) was infused intravenously to chronically catheterized pregnant and nonpregnant female rats. Cardiac output and regional blood flow were measured, and cocaine concentrations in plasma and tissues, as well as plasma cholinesterase activity were determined. Results were compared between pregnant and nonpregnant groups. Cocaine produced a significant decrease in heart rate, accompanied by a fall in cardiac output, and decreased cerebral, myocardial, and placental blood flow in pregnant rats. The plasma cocaine concentration in pregnant animals was lower than that of nonpregnant ones,but tissue concentrations were similar in both groups. These results indicate that pregnancy enhances cardiovascular responses to subtoxic doses of cocaine. There was little placental transfer of cocaine with a fetal to maternal plasma concentration ratio of 0.28.