Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians
Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians
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DOI：
10.1001/archinte.160.7.1025
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发表时间：
2000-04-10
影响因子：
--
通讯作者：
Manson, JE
中科院分区：
文献类型：
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作者：
Ajani, UA;Hennekens, CH;Manson, JE
目的：探讨低至中度饮酒与男性2型糖尿病（DM）发病率之间的关系。设计：前瞻性队列研究。受试者和方法：在平均12.1年的时间里，我们评估了医生健康研究中20951名年龄在40至84岁之间、无心血管疾病、癌症和糖尿病的参与者，并提供了基线时的酒精消耗数据。主要结局指标：随机分组后诊断为2型糖尿病。结果：在20951名医生中，在平均12.1年的随访期间，报告了766例糖尿病。在对年龄、随机治疗分配、吸烟、身体活动和体重指数进行调整后，报告饮酒情况为很少/从不饮酒、每月1至3次饮酒、每周1次饮酒、每周2至4次饮酒、每周5至6次饮酒和每天1次或更多饮酒的患者的相对风险估计值和95%置信区间分别为1.00（参考）、1.03（0.80-1.33）、0.89（0.70-1.14）、0.74（0.59-0.93）、0.67（0.51-0.89）和0.57(0.45-0.73)(线性趋势，P
Objective: To examine the association between low to moderate alcohol consumption and the incidence of type 2 diabetes mellitus (DM) in men.Design: Prospective cohort study.Subjects and Methods: Over an average period of 12.1 years, we evaluated 20 951 participants in the Physicians' Health Study between ages 40 and 84 years who were free of cardiovascular disease, cancer, and diabetes and provided data on alcohol consumption at baseline.Main Outcome Measure: Type 2 DM diagnosed after randomization.Results: Among 20 951 physicians, 766 cases of incident DM were reported over an average follow-up period of 12.1 years. After adjustment for age, randomized treatment assignment, smoking, physical activity, and body mass index, the relative risk estimates and 95% confidence intervals for those reporting alcohol use of rarely/never, 1 to 3 drinks per month, 1 drink per week, 2 to 4 drinks per week, 5 to 6 drinks per week, and 1 or more drinks per day were 1.00 (referent), 1.03 (0.80-1.33), 0.89 (0.70-1.14), 0.74 (0.59-0.93), 0.67 (0.51-0.89), and 0.57 (0.45-0.73), respectively (linear trend, P