Transcutaneous fiber optic Raman spectroscopy of bone using annular illumination and a circular array of collection fibers
Transcutaneous fiber optic Raman spectroscopy of bone using annular illumination and a circular array of collection fibers
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DOI：
10.1117/1.2400233
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发表时间：
2006-11-01
影响因子：
3.5
通讯作者：
Goldstein, Steven A.
中科院分区：
文献类型：
--
作者：
Schulmerich, Matthew V.;Dooley, Kathryn A.;Goldstein, Steven A.
演示了经皮骨拉曼光谱，其具有围绕收集纤维圆形阵列视场的 785 nm 激光激发环。该配置提供分布式激光。环面位于收集纤维视场边缘之外 2 至 3 毫米处，以拒绝来自皮肤和其他覆盖组织的贡献。提供了大鼠和鸡组织的数据。对于大鼠胫骨，在皮肤下 1 mm 深度处测量的碳酸盐/磷酸盐比率在 120 秒积分时间时误差为 2.3%，在 30 秒积分时间误差在 10% 以内。对于皮肤表面以下 4 mm 的鸡胫骨，积分时间为 120 秒时误差小于 8%。 (c) 2006 年光电仪器工程师协会。
Transcutaneous bone Raman spectroscopy with an exciting annulus of 785-nm laser light surrounding the field of view of a circular array of collection fibers is demonstrated. The configuration provides distributed laser light. The annulus is located 2 to 3 mm beyond the edge of the field of view of the collection fibers to reject contributions from skin and other overlying tissues. Data are presented for rat and chicken tissue. For rat tibia, the carbonate/phosphate ratio measured at a depth of 1 mm below the skin is in error by 2.3% at an integration time of 120 s and within 10% at a 30-s integration time. For chicken tibia 4 mm below the skin surface, the error is less than 8% with a 120-s integration time. (c) 2006 Society of Photo-Optical Instrumentation Engineers.