Recruitment for breast cancer predisposition studies in an underserved African American population.
Recruitment for breast cancer predisposition studies in an underserved African American population.
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在服务不足的非裔美国人群体中招募乳腺癌易感性研究。
DOI：
10.1111/j.1075-122x.2005.21542.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Tomlinson,Gail
中科院分区：
文献类型：
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作者：
Patterson,Annette;Davis,Helen;Euhus,David;Neuhausen,Susan;Strong,Louise;Tomlinson,Gail
致编辑：遗传学和技术的最新进展为我们提供了降低乳腺癌相关发病率和死亡率的新工具和策略。随着基因检测的出现，我们现在可以在癌症实际发生之前确定高风险个人和家庭，从而能够实施预防和早期检测战略。然而，所提出的挑战之一是为所有个人，特别是服务不足的少数群体提供平等获得这些技术的机会。高加索人和少数民族之间的乳腺癌生存差异使其成为一个紧迫的优先事项，特别是在死亡率最高的非裔美国人中。减少这些差异的一个步骤是更好地了解病因因素。这些因素包括癌症本身的发展因素，以及早期发现和预防的障碍。为了解决这两个目标，我们已经着手开发一个研究基础设施，以研究非裔美国人中的家族性乳腺癌。根据我们当地的患者人口统计数据，我们主要关注低收入患者及其家庭。高加索人和非洲裔美国妇女之间乳腺癌生存率的差异已得到充分证明（1-5）。2003年国家癌症研究所（NCI）癌症进展报告（6）指出，尽管非洲裔美国妇女患乳腺癌的频率明显低于白人妇女，（分别为每10万人119.8人和139.1人），他们死于疾病的频率更高（每10万人中有34.6例癌症死亡，26.3例癌症死亡）。探索生存差异的潜在因素的研究指出，肿瘤生物学可能存在差异，社会、经济、和文化力量，影响态度和非裔美国人的健康行为（5，7-10）。最近的研究还表明，非洲裔美国人不太可能意识到并参与降低风险的策略，如乳房X光检查和遗传学。
To the Editor: Recent advances in genetics and technology have provided us with new tools and strategies for reducing breast cancer-related morbidity and mortality. With the advent of genetic testing, we can now identify high-risk individuals and families before cancer actually occurs, thus enabling the implementation of prevention and early detection strategies. One of the challenges raised, however, is providing equal access to these technologies for all individuals, especially underserved minority populations. Breast cancer survival disparities between Caucasian and minority populations make this an urgent priority, particularly among African Americans, where mortality rates are highest. One step toward decreasing these disparities is to gain a better understanding of etiologic factors. These include factors in the development of cancer itself, as well as barriers to early detection and prevention. To address both of these aims, we have undertaken the development of a research infrastructure to study familial breast cancer in the African American population. Reflecting our local patient demographics, we have focused primarily on low-income patients and their families. Disparities in breast cancer survival rates between Caucasian and African American women have been well documented (1–5). The 2003 National Cancer Institute (NCI) Cancer Progress Report (6) states that although African American women develop breast cancer significantly less frequently than Caucasian women (119.8 versus 139.1 per 100,000, respectively), they die more frequently from their disease (34.6 versus 26.3 cancer deaths per 100,000).Research exploring the underlying factors in survival disparities has pointed to possible differences in tumor biology and an extraordinary convergence of social, economic, and cultural forces that influence attitudes and health behaviors among African Americans (5, 7–10). More recent research has also shown that African Americans are less likely to be aware of and participate in riskreducing strategies such as mammography and genetic