ADVERSE REACTIONS TO ACETYLCYSTEINE AND EFFECTS OF OVERDOSE
ADVERSE REACTIONS TO ACETYLCYSTEINE AND EFFECTS OF OVERDOSE
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DOI：
10.1136/bmj.289.6439.217
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发表时间：
1984-01-01
影响因子：
105.7
通讯作者：
TALBOT, JCC
中科院分区：
文献类型：
--
作者：
MANT, TGK;TEMPOWSKI, JH;TALBOT, JCC
自1979年引入静脉注射乙酰半胱氨酸（Parvolex）作为对乙酰氨基酚过量的解毒剂以来，国家毒物信息服务中心[伦敦，英国]和生产商收到了38起类速发过敏反应性质的不良反应和19起意外过量。对正常剂量的类速发过敏反应的最常见特征是皮疹;报告的其他特征包括血管性水肿、低血压和支气管痉挛;所有患者均痊愈。与乙酰半胱氨酸过量相关的特征相似，但更严重; 2例患者死亡，但两例病例中乙酰半胱氨酸过量可能涉及的程度尚不清楚。
Since the introduction in 1979 of i.v. acetylcysteine (Parvolex) as an antidote for overdosage of paracetamol the National Poisons Information Service [London, UK] and the manufacturer were notified of 38 adverse reactions that were anaphylactoid in nature and 19 accidental overdoses. The most common feature of the anaphylactoid reaction to normal dosage was rash; other features reported included angioedema, hypotension and bronchospasm; all the patients recovered. The features associated with an overdose of acetylcysteine were similar but more severe; 2 patients died, but the extent to which the overdose of acetylcysteine may have been implicated was not clear in either case.