Adherence to the Eatwell Guide and cardiometabolic, cognitive and neuroimaging parameters: An analysis from the PREVENT Dementia study
Adherence to the Eatwell Guide and cardiometabolic, cognitive and neuroimaging parameters: An analysis from the PREVENT Dementia study
复制标题
遵守 Eatwell 指南以及心脏代谢、认知和神经影像学参数：预防痴呆研究的分析
DOI：
10.1101/2023.05.09.23289734
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Gregory S
中科院分区：
文献类型：
--
作者：
Gregory S
Eatwell指南反映了英国政府对健康均衡饮食的建议。以前的研究已经确定了健康的饮食模式与心血管和大脑健康之间的联系，尽管很少有证据特别关注Eatwell指南。到目前为止，还没有研究调查Eatwell指南与未来痴呆症风险之间的关系。本分析使用了PREVENT痴呆队列研究基线访视的数据。根据自我报告的食物频率问卷创建二元和分级Eatwell Guide评分（BEWG、GEWG）。CAIDE评分作为主要结果指标，代表未来阿尔茨海默病的风险。次要结局指标包括心脏代谢健康指标和脑健康指标。广义加性模型在R.共有517名参与者被纳入分析，平均BEWG评分为4.39（± 1.66）（满分12分），GEWG评分为39.88（± 6.19）（满分60分）。Eatwell Guide评分与CAIDE评分（BEWG β：0.07，95%置信区间（CI）：-0.07，0.22; GEWG β：0.02，95% CI：-0.02，0.06）或任何脑健康指标之间均无显著相关性。较高的GEWG评分与较低的收缩压、舒张压和体重指数（BMI）之间存在显著相关性（收缩压β：-0.24，95% CI：-0.45，-0.03;舒张压β：-0.16，95% CI：-0.29，-0.03; BMI β：-0.09，95% CI：-0.16，-0.01）。虽然与CAIDE评分没有直接关系，但Eatwell指南饮食模式可能有助于通过改变高血压和肥胖来预防痴呆症，这两种疾病都是痴呆症的已知危险因素。未来的工作可以在其他英国队列中复制这些发现，并进一步开发Eatwell Guide评分方法。
The Eatwell guide reflects the UK government's recommendations for a healthy and balanced diet. Previous research has identified associations between healthy eating patterns and both cardiovascular and brain health, although there is little evidence specifically focusing on the Eatwell Guide. To date no research has investigated associations between the Eatwell Guide and risk for future dementia. Data from the PREVENT dementia cohort study baseline visit was used in this analysis. Binary and graded Eatwell Guide scores (BEWG, GEWG) were created from a self-reported Food Frequency Questionnaire. The CAIDE score was included as the primary outcome measure to represent risk for future Alzheimer’s disease. Secondary outcome measures included cardiometabolic health measures and brain health measures. Generalised additive models were run in R. A total of 517 participants were included in the analysis, with a mean BEWG score of 4.39 (± 1.66) (out of a possible 12 points) and GEWG score of 39.88 (± 6.19) (out of a possible 60 points). There was no significant association between either Eatwell Guide score and the CAIDE score (BEWG β: 0.07, 95% confidence interval (CI): -0.07, 0.22; GEWG β: 0.02, 95% CI: -0.02, 0.06) or any measures of brain health. There was a significant association between higher GEWG score and lower systolic and diastolic blood pressure and body mass index (BMI) (systolic β: -0.24, 95% CI: -0.45, -0.03; diastolic β: -0.16, 95% CI: -0.29, -0.03; BMI β: -0.09, 95% CI: -0.16, -0.01). Although not directly associated with the CAIDE score, the Eatwell Guide dietary pattern may be beneficial for dementia prevention efforts through the modification of hypertension and obesity, which are both known risk factors for dementia. Future work could replicate these findings in other UK-based cohorts as well as further development of Eatwell Guide scoring methodologies.