Risk of cardiovascular events in mothers of women with polycystic ovary syndrome.
Risk of cardiovascular events in mothers of women with polycystic ovary syndrome.
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DOI：
10.4158/ep.14.9.1084
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发表时间：
2008-12
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本研究的目的是评估老年多囊卵巢综合征（PCOS）妇女心血管事件的患病率。我们利用多囊卵巢综合征的高遗传性，确定了多囊卵巢综合征妇女的母亲可能的多囊卵巢综合征状态。测定PCOS和非PCOS母亲心血管事件的患病率。在一个内分泌诊所，308名PCOS妇女接受了关于其母亲病史的采访，如果可以的话，母亲本人也接受了采访。访谈内容包括月经史、生育能力、高雄激素血症的临床体征、心血管事件发生年龄和女儿报告的死亡年龄。PCOS的母亲被定义为不孕症史、月经不规律或高雄激素血症的临床体征。心血管事件定义为致死性或非致死性心肌梗死、任何冠状动脉介入治疗、需要急诊室访视的心绞痛或脑血管事件。母亲主要是绝经后妇女。在182位受访（n=157）或已故（n=25）母亲中，59位可能患有PCOS。心血管事件在PCOS母亲中（11/59或18.6%）比非PCOS母亲（5/123或4.1%）更常见（p=0.011）。经年龄和种族调整后，可能的PCOS是心血管事件的独立预测因子（OR 5.41 95%CI 1.78 - 16.40）。心血管事件发生在PCOS妇女的母亲，特别是PCOS本身的母亲的早期年龄。与非PCOS母亲相比，PCOS母亲的心血管事件风险更高，并且心血管事件似乎发生在PCOS母亲的预期年龄之前。
The purpose of this study was to assess the prevalence of cardiovascular events in an older population of women with polycystic ovary syndrome (PCOS). We took advantage of the high heritability of PCOS and determined the probable PCOS status of mothers of women with PCOS. Prevalence of cardiovascular events in PCOS and non-PCOS mothers was determined. In a single endocrine clinic, 308 women with PCOS were interviewed about their mothers’ medical history, and the mothers themselves were interviewed if available. The interview covered menstrual history, fertility, clinical signs of hyperandrogenism, age of incident cardiovascular event, and age of death as reported by daughters. Presence of PCOS in the mothers was defined as history of infertility, irregular menses, or clinical signs of hyperandrogenism. Cardiovascular event was defined as fatal or nonfatal myocardial infarction, any coronary intervention, angina requiring emergency room visits, or cerebrovascular event. The mothers were predominantly postmenopausal. Among 182 interviewed (n=157) or deceased (n=25) mothers, 59 had probable PCOS. Cardiovascular events were more common (p=0.011) among PCOS mothers (11/59 or 18.6%) than non-PCOS mothers (5/123 or 4.1%). Adjusted for age and race, probable PCOS was an independent predictor of cardiovascular events (OR 5.41 95%CI 1.78−16.40). Cardiovascular events occurred at an early age in mothers of PCOS women, particularly mothers with PCOS themselves. PCOS mothers of women with PCOS are at a higher risk of cardiovascular events compared with non-PCOS mothers, and cardiovascular events appear to occur at an earlier than expected age in PCOS mothers.