Induction of virus resistance by exogenous application of double-stranded RNA
Induction of virus resistance by exogenous application of double-stranded RNA
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DOI：
10.1016/j.coviro.2017.07.009
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发表时间：
2017-10-01
影响因子：
5.9
通讯作者：
Carroll, Bernard J.
中科院分区：
文献类型：
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作者：
Mitter, Neena;Worrall, Elizabeth A.;Carroll, Bernard J.
Exogenous application of double-stranded RNA (dsRNA) for virus resistance in plants represents a very attractive alternative to virus resistant transgenic crops or pesticides targeting virus vectors. However, the instability of dsRNA sprayed onto plants is a major challenge as spraying naked dsRNA onto plants provides protection against homologous viruses for only 5 days. Innovative approaches, such as the use of nanoparticles as carriers of dsRNA for improved stability and sustained release, are emerging as key disruptive technologies. Knowledge is still limited about the mechanism of entry, transport and processing of exogenously applied dsRNA in plants. Cost of dsRNA and regulatory framework will be key influencers towards practical adoption of this technology.
