Platelets: linking hemostasis and cancer.
Platelets: linking hemostasis and cancer.
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DOI：
10.1161/atvbaha.110.207514
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Ware J
中科院分区：
文献类型：
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作者：
Jain S;Harris J;Ware J
血小板是血液中负责通过止血维持心血管系统完整性的主要细胞成分。血小板功能障碍导致广泛的明显病理状态，例如出血或血栓形成，但正常的血小板功能也与不直接与止血或血栓形成相关的疾病有关，例如癌症。自从1865年描述Trousseau综合征以来，各种实验和临床证据详细说明了血小板与原发性肿瘤和循环转移性肿瘤细胞的相互作用。观察表明，血小板不仅通过血管生成增加原发性肿瘤的生长，而且赋予肿瘤细胞物理和机械支持以逃避免疫系统和外渗到继发性器官，这是转移性疾病的基础。许多实验室和动物研究已经确定了抗血小板治疗的特异性靶点，这可能有利于目前的癌症治疗。本文综述了血小板在分子水平上影响肿瘤发生，包括原发性肿瘤生长和转移的重要特性。这些研究提供了血小板止血和肿瘤发生的充分研究范例之间的联系。
Platelets are the main cellular component in blood responsible for maintaining the integrity of the cardiovascular system via hemostasis. Platelet dysfunction contributes to a wide range of obvious pathologic conditions, such as bleeding or thrombosis, but normal platelet function is also linked to diseases not immediately associated with hemostasis or thrombosis, such as cancer.Since the description of Trousseau’s syndrome in 1865 various experimental and clinical evidences have detailed the interaction of platelets with primary tumors and circulating metastatic tumor cells. Observations have suggested that platelets not only augment the growth of primary tumors via angiogenesis but endow tumor cells physical and mechanical support to evade the immune system and extravasate to secondary organs, the basis of metastatic disease.Many laboratory and animal studies have identified specific targets for anti-platelet therapy which may be advantageous as adjuncts to current cancer treatments. In this review, we summarize important platelet properties which influence tumorigenesis including primary tumor growth and metastasis at the molecular level. The studies provide a link between the well-studied paradigms of platelet hemostasis and tumorigenesis.