The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
复制标题
DOI：
10.1016/j.cmet.2005.03.004
复制
发表时间：
2005-04-01
期刊：
影响因子：
29
通讯作者：
Fafournoux, P
中科院分区：
文献类型：
--
作者：
Maurin, AC;Jousse, C;Fafournoux, P
为了确保足够的营养供应，杂食动物在可用的食物来源中进行选择。这一过程的例证是杂食动物对氨基酸含量不平衡的营养食物的先天厌恶。我们报告说，脑特异性失活GCN 2，一种普遍表达的蛋白激酶，磷酸化翻译起始因子2 α（eIF2 α）在细胞内氨基酸缺乏的反应，削弱这种厌恶的反应。GCN 2失活也降低了小鼠前梨状皮质中磷酸化eIF2 α水平，随后消耗不平衡膳食。一个古老的细胞内信号转导途径对氨基酸缺乏作出反应，从而通过激活一个神经元回路来影响摄食行为，该神经元回路使消费偏向于不平衡的食物来源。
To insure an adequate supply of nutrients, omnivores choose among available food sources. This process is exemplified by the well-characterized innate aversion of omnivores to otherwise nutritious foods of imbalanced amino acid content. We report that brain-specific inactivation of GCN2, a ubiquitously expressed protein kinase that phosphorylates translation initiation factor 2 alpha (eIF2 alpha) in response to intracellular amino acid deficiency, impairs this aversive response. GCN2 inactivation also diminishes phosphorylated eIF2 alpha levels in the mouse anterior piriform cortex following consumption of an imbalanced meal. An ancient intracellular signal transduction pathway responsive to amino acid deficiency thus affects feeding behavior by activating a neuronal circuit that biases consumption against imbalanced food sources.