Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preference
Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preference
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DOI：
10.1006/appe.1999.0274
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发表时间：
2000-02-01
期刊：
影响因子：
5.4
通讯作者：
Koh, MT
中科院分区：
文献类型：
--
作者：
Lett, BT;Grant, VL;Koh, MT
轮跑强化了之前的行为，而且，轮跑可以产生活动性厌食，这是对食物限制的大鼠进食的显著抑制。一些作者提出，活动性厌食效应是由调节强化效应的同一奖励系统的激活产生的。一种假设是，这种激活持续后，车轮运行停止，并在一个奖励的后效，抑制喂养的结果。或者，这种激活可能会引起一种对抗过程，一种抑制进食的厌恶性后效。采用位置条件化的方法来检验车轮运行的后效是奖励性的还是厌恶性的。食物剥夺的大鼠接受了一个独特的房间与车轮运行的后效配对。在实验1中，2小时的运行轮，然后在一个独特的腔室30分钟产生条件性位置偏好。在实验2中，在转轮中22-22.5小时，随后在腔室中30分钟，然后进行60分钟的喂养试验。轮跑抑制摄食，产生条件性位置偏好。条件性位置偏好表明，车轮运行的后效是加强而不是厌恶。这一发现支持了这样一种观点，即奖励系统的激活在车轮停止运行后仍然存在，从而抑制了食物的摄入。(C)北京大学出版社.
Wheel running reinforces behavior that precedes it. Also, wheel running can produce activity anorexia, a marked suppression of feeding in food-restricted rats. Some authors propose that the activity anorexia effect is produced by activation of the same reward system that mediates the reinforcing effect. One hypothesis is that such activation persists after wheel running stops and results in a rewarding aftereffect that suppresses feeding. Alternatively, such activation may give rise to an opponent process, an aversive aftereffect that suppresses feeding. The method of place conditioning was used to test whether the aftereffect of wheel running is rewarding or aversive. Food-deprived rats received pairings of a distinctive chamber with the aftereffect of wheel running. In Experiment 1, 2 h in a running wheel followed by 30 min in a distinctive chamber produced conditioned place preference. In Experiment 2, 22-22.5 h in a running wheel was followed by 30 min in the chamber and then a 60-min feeding test. Wheel running suppressed feeding and produced conditioned place preference. The conditioned place preference indicates that the aftereffect of wheel running is reinforcing rather than aversive. This finding supports the idea that the activation of the reward system persists after wheel running stops, thereby suppressing food intake. (C) 2000 Academic Press.