The role of human papillomaviruses in anogenital cancers
The role of human papillomaviruses in anogenital cancers
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DOI：
10.1006/scbi.1998.0081
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发表时间：
1998-08-01
影响因子：
14.5
通讯作者：
Frisch, M
中科院分区：
文献类型：
--
作者：
Melbye, M;Frisch, M
有大量证据表明，存在宫颈癌和其他肛门生殖器癌的共同风险因素。子宫颈癌的病因学与性病类型的人乳头瘤病毒（HPV）有关。在其他肛门生殖器组织中也发现了相同类型的HPV。问题是这些HPV类型在多大程度上也可能导致宫颈癌以外的肛门生殖器癌的致癌作用。在这篇综述中，我们介绍了HPV自然史的一些一般方面，然后描述了肛门癌、外阴癌和阴茎癌的发病率和危险因素。主要重点是这些癌症与HPV之间存在关联的证据。
There is substantial evidence to suggest that common risk factors exist for cancer of the cervix and other anogenital cancers. Cervical cancer has been etiologically linked with venereal types of human papillomavirus (HPV) and the. same types of HPV are being found in other anogenital tissues. The question is to what extent these HPV types may also contribute to carcinogenesis in anogenital cancer other than cervical cancer. In this review some general aspects of the natural history of HPV are presented followed by a description of the incidence and risk factors for anal, vulvar, and penile cancer. Main focus is given to the evidence for an association between these cancers and HPV.