Evolution of Sex-Biased Gene Expression and Dosage Compensation in the Eye and Brain of Heliconius Butterflies
Evolution of Sex-Biased Gene Expression and Dosage Compensation in the Eye and Brain of Heliconius Butterflies
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DOI：
10.1093/molbev/msy111
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发表时间：
2018-09-01
影响因子：
10.7
通讯作者：
Briscoe, Adriana D.
中科院分区：
文献类型：
--
作者：
Catalan, Ana;Macias-Munoz, Aide;Briscoe, Adriana D.
女性和男性在行为和生活史特征上的差异是性别之间不同选择压力的基础。有人建议，两性应对不同生活史要求的一种方法是通过性别偏见的基因表达。在这项研究中，我们对来自五个赫利柯斯种的眼睛和大脑的联合转录组进行了性别偏见的比较基因表达分析，它们分别是H.charithonia、H.Sara、H.Erato、H.Melpomene和H.Doris，它们代表了赫利柯斯系统发育的五个主要分支。我们发现，在基因表达中，性别二型性的程度在赫利柯乌斯中并不保守。在每个物种中发现的大多数性别偏见基因在任何其他物种中都没有性别偏见，这表明性别选择可能驱动了性别二态基因的表达。只有三个基因在多个物种中共享性别偏见的表达：紫外线视蛋白UVRh1和果蝇的同源基因Kriippel-Homolog 1和CG9492。我们还观察到，在一些物种中，偏向于女性的基因具有更高的进化率，但在另一些物种中，偏向于男性的基因表现出比非偏向基因更快的进化速度，这表明驱动赫利柯伊斯性别偏向基因进化的选择性力量以性别和物种特有的方式发挥作用。此外，我们在所有被测试的卷蛾中都发现了剂量补偿，这为整个鳞翅目的剂量补偿的保存提供了额外的证据。最后，性别偏见基因在Z上显著丰富，这种模式可能是性别对抗选择的结果。
Differences in behavior and life history traits between females and males are the basis of divergent selective pressures between sexes. It has been suggested that a way for the two sexes to deal with different life history requirements is through sex-biased gene expression. In this study, we performed a comparative sex-biased gene expression analysis of the combined eye and brain transcriptome from five Heliconius species, H. charithonia, H. sara, H. erato, H. melpomene and H. doris, representing five of the main clades from the Heliconius phylogeny. We found that the degree of sexual dimorphism in gene expression is not conserved across Heliconius. Most of the sex-biased genes identified in each species are not sex-biased in any other, suggesting that sexual selection might have driven sexually dimorphic gene expression. Only three genes shared sex-biased expression across multiple species: ultraviolet opsin UVRh1 and orthologs of Drosophila Kriippel-homolog 1 and CG9492. We also observed that in some species female-biased genes have higher evolutionary rates, but in others, male-biased genes show the fastest rates when compared with unbiased genes, suggesting that selective forces driving sex-biased gene evolution in Heliconius act in a sex- and species-specific manner. Furthermore, we found dosage compensation in all the Heliconius tested, providing additional evidence for the conservation of dosage compensation across Lepidoptera. Finally, sex-biased genes are significantly enriched on the Z, a pattern that could be a result of sexually antagonistic selection.