Insulin-stimulated glucose uptake and fasting blood glucose.
Insulin-stimulated glucose uptake and fasting blood glucose.
复制标题
胰岛素刺激的葡萄糖摄取和空腹血糖。
DOI：
10.1507/endocrj1954.38.421
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
H. Kuzuya
中科院分区：
文献类型：
--
作者：
M. Okamoto;M. Okamoto;H. Nishimura;A. Kosaki;S. Kono;G. Inoue;I. Maeda;M. Kubota;T. Hayashi;H. Kuzuya
应用葡萄糖钳夹技术研究了青年和老年受试者、糖耐量减低受试者和NIDDM患者胰岛素刺激的糖代谢变化。糖尿病组包括未接受胰岛素治疗的肥胖和非肥胖患者以及接受胰岛素治疗的非肥胖患者。与年轻对照组（7.4 +/- 0.3 mg/kg/min）相比，老年受试者的葡萄糖处置率（GDR）降低（5.8 +/- 0.4 mg/kg/min）。在IGT患者中，其进一步降低至3.6 +/- 0.5 mg/kg/min，与未接受胰岛素治疗的NIDDM患者的速率（3.3 +/- 0.4 mg/kg/min）相当。肥胖（3.0 +/- 0.3 mg/kg/min）和非肥胖（3.4 +/- 0.6 mg/kg/min）糖尿病患者之间的GDR无差异。在接受胰岛素治疗的糖尿病患者中，GDR范围很广，但平均值部分正常化（5.2 +/- 0.9 mg/kg/min）。糖尿病组空腹血糖与GDR无相关性。这些结果表明，在NIDDM的发展过程中，胰岛素刺激的葡萄糖摄取的减少先于空腹血糖的升高。因此，如先前报道的高加索NIDDM患者，胰岛素刺激的葡萄糖摄取抵抗可能是日本NIDDM患者的基本缺陷之一。然而，胰岛素抵抗的程度与胰岛素作用缺陷的程度没有直接关系。
Changes in insulin-stimulated glucose metabolism were studied in young and aged subjects, subjects with impaired glucose tolerance, and patients with NIDDM by means of the glucose clamp technique. The diabetic group includes obese and non-obese patients treated without insulin and non-obese patients treated with insulin. The glucose disposal rate (GDR) was decreased in aged subjects (5.8 +/- 0.4 mg/kg/min) compared with young controls (7.4 +/- 0.3 mg/kg/min). In patients with IGT, it was further decreased to 3.6 +/- 0.5 mg/kg/min, which was comparable to the rate in NIDDM without insulin treatment (3.3 +/- 0.4 mg/kg/min). There were no differences in the GDR between obese (3.0 +/- 0.3 mg/kg/min) and non-obese (3.4 +/- 0.6 mg/kg/min) diabetic patients. In insulin-treated diabetic patients, GDR ranged widely, but the mean value was partially normalized (5.2 +/- 0.9 mg/kg/min). In the diabetic group, no correlation was observed between fasting blood glucose and GDR. These results suggest that in the course of developing NIDDM, a decrease in insulin-stimulated glucose uptake precedes a rise in fasting blood glucose. Thus, as previously reported for Caucasian NIDDM patients, resistance to insulin-stimulated glucose uptake may be one of the basic defects in Japanese patients with NIDDM. The degree of glycemia, however, is not directly related to the magnitude of the defect in insulin action.
影响因子：
15.9
作者：
FERRANNINI, E;BARRETT, EJ;DEFRONZO, RA
通讯作者：
DEFRONZO, RA