Awake hippocampal reactivations project onto orthogonal neuronal assemblies
Awake hippocampal reactivations project onto orthogonal neuronal assemblies
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DOI：
10.1126/science.aaf3319
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发表时间：
2016-09-16
期刊：
影响因子：
56.9
通讯作者：
Cossart, Rosa
中科院分区：
文献类型：
--
作者：
Malvache, Arnaud;Reichinnek, Susanne;Cossart, Rosa
神经元组装的链式激活被认为支持主要的认知过程，包括记忆。在海马体中，这是在群体爆发期间观察到的，通常与尖锐波波纹有关，以神经元有序重新激活的形式。然而，这些组件的组织和寿命仍然未知。我们使用钙成像来绘制清醒小鼠在跑步机上跑步时CA1区同步神经元激活的模式。这些模式是由解剖学上混合但功能上正交的组装体的反复激活组成的。这些组件重新激活离散的时间段的神经元序列在运行过程中观察到的，可以在连续几天稳定。这些组装体结合成更长的链揭示了时间有序的重播。这些模块可以表示用于编码或检索经验的默认构建块。
The chained activation of neuronal assemblies is thought to support major cognitive processes, including memory. In the hippocampus, this is observed during population bursts often associated with sharp-wave ripples, in the form of an ordered reactivation of neurons. However, the organization and lifetime of these assemblies remain unknown. We used calcium imaging to map patterns of synchronous neuronal activation in the CA1 region of awake mice during runs on a treadmill. The patterns were composed of the recurring activation of anatomically intermingled, but functionally orthogonal, assemblies. These assemblies reactivated discrete temporal segments of neuronal sequences observed during runs and could be stable across consecutive days. A binding of these assemblies into longer chains revealed temporally ordered replay. These modules may represent the default building blocks for encoding or retrieving experience.