PROCEEDINGS OF THE
PROCEEDINGS OF THE
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DOI：
10.1111/j.1365-2125.2006.02665.x
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
A. N. Nicholson;A. W. Peck
中科院分区：
文献类型：
--
作者：
A. N. Nicholson;A. W. Peck
Clinical studies (e.g. Hardy & Wakely, 1962; Pandit & Dundee, 1970) have emphasized the amnesic properties of hyoscine in routine anaesthetic practice. In a previous experiment (Crow & Grove-White, 1973) we demonstrated that hyoscine impairs performance on a simple verbal learning task to a greater extent at longer (e.g. 5-60 s) than at shorter (e.g. less than 5 s) intervals before recall, and that this impairment is selective to a learning as compared to a scanning task. In the present experiments we have examined whether this action distinguishes hyoscine from other classes of central depressant drug. Eight male subjects (age 19-23 years) were given a scanning task, and a free-recall learning test, with an immediate and delayed component, after various drug treatments given i.v. on each of five occasions. The results (Table 1) show that
