Defining the cancer master switch.
Defining the cancer master switch.
复制标题
定义癌症总开关。
DOI：
10.1007/s00268-010-0941-2
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发表时间：
2011
影响因子：
2.6
通讯作者：
Brunicardi,FCharles
中科院分区：
文献类型：
--
作者：
Balentine,CourtneyJ;Berger,DavidH;Liu,Shi-He;Chen,Changyi;Nemunaitis,John;Brunicardi,FCharles
背景最近的研究重点是信号级联及其相互作用，对靶向哪些遗传途径以及它们在肿瘤中如何发生改变有了相当深入的了解。现在可以根据对肿瘤生长和存活至关重要的途径的知识来设计治疗干预措施。这些关键的干预目标，癌症的主开关，被称为这样，因为肿瘤试图“翻转开关”的方式，促进其生存，而分子治疗的目的是“关闭”信号重要的肿瘤相关processes.MethodsLiterature review.ConclusionsDefining有用的治疗目标取决于识别的途径，是至关重要的肿瘤生长，生存和转移。由于并非所有的信号级联都是平等的，因此需要以系统的方式选择主开关或干预目标。本讨论提出了一组标准来定义癌症主开关的含义，并提供了示例来说明其应用。
BackgroundRecent research has focused on signaling cascades and their interactions yielding considerable insight into which genetic pathways are targeted and how they tend to be altered in tumors. Therapeutic interventions now can be designed based on the knowledge of pathways vital to tumor growth and survival. These critical targets for intervention, master switches for cancer, are termed so because the tumor attempts to “flip the switch” in a way that promotes its survival, whereas molecular therapy aims to “switch off” signals important for tumor-related processes.MethodsLiterature review.ConclusionsDefining useful targets for therapy depends on identifying pathways that are crucial for tumor growth, survival, and metastasis. Because not all signaling cascades are created equal, selecting master switches or targets for intervention needs to be done in a systematic fashion. This discussion proposes a set of criteria to define what it means to be a cancer master switch and provides examples to illustrate their application.