Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family members.
Childhood-onset schizophrenia: smooth pursuit eye-tracking dysfunction in family members.
复制标题
儿童期发病的精神分裂症：家庭成员的平滑追踪眼球追踪功能障碍。
DOI：
10.1016/j.schres.2004.07.020
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发表时间：
2005
影响因子：
4.5
通讯作者：
Rapoport,JudithL
中科院分区：
文献类型：
--
作者：
Sporn,Alexandra;Greenstein,Deanna;Gogtay,Nitin;Sailer,Franziska;Hommer,DanielW;Rawlings,Robert;Nicolson,Rob;Egan,MichaelF;Lenane,Marge;Gochman,Peter;Weinberger,DanielR;Rapoport,JudithL
BACKGROUNDChildhood-onset schizophrenia (COS), a severe form of the disorder, is of interest for etiologic studies. Smooth pursuit eye-tracking dysfunction (ETD) is a biological marker for schizophrenia.AIMSTo compare familial eye-tracking abnormalities for COS and adult-onset schizophrenia (AOS).METHODEye-tracking performance for 70 COS parents, 64 AOS parents and 20 COS siblings was compared to their respective age-matched control groups.RESULTSCOS and AOS parents had higher rate of dichotomously rated eye-tracking dysfunction than their respective controls (16% vs. 1% and 22% vs. 4%, respectively). COS parents and siblings also differed from controls on several continuous measures. However, scores for COS, AOS and control groups overlapped extensively.CONCLUSIONSGenetic factors underlying eye-tracking dysfunction appear more salient for COS. However, eye-tracking measures have to be used with caution for endophenotypic definition due to low predictive power.DECLARATION OF INTERESTThe study was done at the National Institutes of Health.
