Delayed non-matching to position performance in aged hybrid Fischer 344 x Brown Norway rats: a longitudinal study
Delayed non-matching to position performance in aged hybrid Fischer 344 x Brown Norway rats: a longitudinal study
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DOI：
10.1016/j.brainresbull.2004.04.017
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发表时间：
2004-07-30
影响因子：
3.8
通讯作者：
van der Staay, FJ
中科院分区：
文献类型：
--
作者：
Blokland, A;Sik, A;van der Staay, FJ
在这项研究中，在杂交 Fischer 344 x Brown挪威大鼠中纵向研究了衰老对延迟不匹配位置 (DNMTP) 任务表现的影响。首先训练老鼠执行任务。随后，他们在 28 至 34 个月大时每月评估一次表现。在研究过程中，对 DNMTP 时间表的响应措施并未减少。最后一次 DNMTP 测试后，测量额叶皮层和海马的胆碱乙酰转移酶 (ChAT) 活性和胶质纤维酸性蛋白 (GFAP) 含量。我们发现，额叶皮层（而非海马体）中较高水平的 GFAP 与 DNMTP 任务中的较差表现相关。我们的研究结果支持了横断面研究中报道的重复测试可以防止与年龄相关的认知功能下降的观点。额叶皮层的病理学似乎预示着衰老大鼠的遗忘速度更快。 (C) 2004 Elsevier Inc. 保留所有权利。
In this study, the effects of aging on the performance in a delayed non-matching to position (DNMTP) task were investigated longitudinally in hybrid Fischer 344 x Brown Norway rats. The rats were first trained to perform the task. Subsequently, their performance was assessed monthly from 28 to 34 months of age. The measures of responding on the DNMTP schedule did not decrease in the course of the study. After the last DNMTP test, choline acetyltransferase (ChAT) activity and glial fibrillary acidic protein (GFAP) content were measured in frontal cortex and hippocampus. We found that higher levels of GFAP in the frontal cortex, but not hippocampus, were associated with a poorer performance in the DNMTP task. Our findings support the notion that repeated testing prevents the age-related decline in cognitive functions that has been reported in cross-sectional studies. Pathology of the frontal cortex seems to predict a faster rate of forgetting in aging rats. (C) 2004 Elsevier Inc. All rights reserved.