THE ROLES OF INFLAMMATORY CELLS IN THE PATHOGENESIS OF ASTHMA AND OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
THE ROLES OF INFLAMMATORY CELLS IN THE PATHOGENESIS OF ASTHMA AND OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
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DOI：
10.1164/ajrccm/143.5_pt_1.1165
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发表时间：
1991-05-01
期刊：
影响因子：
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通讯作者：
KAY, AB
中科院分区：
文献类型：
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作者：
CORRIGAN, CJ;KAY, AB
哮喘和慢性阻塞性肺疾病（COPD）的定义仍然完全是功能性的，这阻碍了发病机制的研究，特别是因为这两种疾病的许多异常表现出一定程度的重叠。哮喘通常被定义为可逆性气道阻塞（1），并伴有非特异性支气管高反应性（BHR）。BHR似乎与疾病严重程度（2）和治疗需求（3）相关。另一方面，慢性阻塞性肺疾病可定义为不可逆的小气道阻塞，尽管不可逆的气道阻塞也可使慢性哮喘复杂化[4]。粘液高分泌是部分COPD患者的特征。此外，在COPD患者中证实了非特异性BHR（5，6），尽管这可能仅仅反映了基线气道口径减小的机械效应（6）。
Definition of Asthma and COPO The definition of both asthma and chronic obstructive pulmonary disease (COPD) remain entirely functional, and this has hindered studies of pathogenesis, particularly because many of the abnormalities in the two diseases demonstrate a degree of overlap. Asthma is generally defined as reversible airwayobstruction (1) with nonspecific bronchial hyperresponsiveness (BHR) as an additional important feature. BHR appears to correlate with disease severity (2) and the need for therapy (3). COPD, on the other hand, can be defined in terms of irreversible obstruction of the small airways, although irreversibleairway obstruction also can complicate chronic asthma (4). Mucus hypersecretion is a feature of COPD in some patients. Nonspecific BHR has, in addition, been demonstrated in patients with COPD (5, 6) although this may simply reflect the mechanical effect of reduced baseline airway caliber (6).