Sweet bays of ERAD.
Sweet bays of ERAD.
复制标题
ERAD 的甜蜜海湾。
DOI：
10.1016/j.tibs.2008.04.013
复制
发表时间：
2008
影响因子：
13.8
通讯作者：
Hebert,DanielN
中科院分区：
文献类型：
--
作者：
Tamura,Taku;Cormier,JamesH;Hebert,DanielN
在内质网（ER）中不适当成熟的蛋白质被移位到细胞质中进行蛋白酶体介导的破坏。最近的一项研究提供了对ER相关蛋白降解的异常蛋白的选择和靶向的不完全理解的过程的见解。ER伴侣GRP 94和BiP作为甘露糖结合蛋白OS-9和XTP 3-B的结合伴侣的鉴定表明，这些蛋白质复合物与异常蛋白质结合，并将它们引导至ER膜中的Hrd 1位错和泛素化复合物。
Proteins that improperly mature in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for proteasome-mediated destruction. A recent study provides insight into the incompletely understood processes for selection and targeting of aberrant proteins for ER-associated protein degradation. The identification of the ER chaperones GRP94 and BiP as binding partners for the mannose-binding proteins OS-9 and XTP3-B, indicates that these protein complexes bind to aberrant proteins and direct them to the Hrd1 dislocation and ubiquitylation complex in the ER membrane.