Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions
Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions
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DOI：
10.1021/ja8058843
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发表时间：
2009-02-18
影响因子：
15
通讯作者：
Kimizuka, Nobuo
中科院分区：
文献类型：
--
作者：
Nishiyabu, Ryuhei;Hashimoto, Nozomi;Kimizuka, Nobuo
非晶态纳米粒子的超分子配位聚合物网络是自发自组装的核苷酸和镧系离子在水中。它们具有固有的功能，如从核碱基到镧系离子的能量转移，以及作为磁共振成像（MRI）造影剂的优异性能。此外，在自组装过程中观察到自适应包合特性：荧光染料、金属纳米粒子和蛋白质等功能材料被很容易地封装。这些纳米颗粒中的染料以高量子产率发出荧光，呈单指数衰减，表明客体分子以单体形式包裹在网络中。金纳米粒子和铁蛋白也被超分子壳包裹。此外，这些核苷酸/镧系纳米颗粒还可以作为固定化酶的支架。目前超分子纳米颗粒的适应性提供了一个多功能平台，可用于从材料到生物医学科学的各种应用。举例说明了其在体内组织定位实验中的生物相容性和肝脏定向特性。
Amorphous nanoparticles of supramolecular coordination polymer networks are spontaneously self-assembled from nucleotides and lanthanide ions in water. They show intrinsic functions such as energy transfer from nucleobase to lanthanide ions and excellent performance as contrast enhancing agents for magnetic resonance imaging (MRI). Furthermore, adaptive inclusion properties are observed in the self-assembly process: functional materials such as fluorescent dyes, metal nanoparticles, and proteins are facilely encapsulated. Dyes in these nanoparticles fluoresce in high quantum yields with a single exponential decay, indicating that guest molecules are monomerically wrapped in the network. Gold nanoparticles and ferritin were also wrapped by the supramolecular shells. In addition, these nucleotide/lanthanide nanoparticles also serve as scaffolds for immobilizing enzymes. The adaptive nature of present supramolecular nanoparticles provides a versatile platform that can be utilized in a variety of applications ranging from material to biomedical sciences. As examples, biocompatibility and liver-directing characteristics in in vivo tissue localization experiments are demonstrated.