Immune responses to gut microbiota-commensals and pathogens
Immune responses to gut microbiota-commensals and pathogens
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DOI：
10.4161/gmic.1.4.12613
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发表时间：
2010-07
期刊：
影响因子：
12.2
通讯作者：
T. Tanoue;Y. Umesaki;K. Honda
中科院分区：
文献类型：
--
作者：
T. Tanoue;Y. Umesaki;K. Honda
哺乳动物的消化道含有数百种与宿主免疫系统密切相互作用的共生微生物。在肠道内，免疫系统积极与潜在的致病微生物反应，同时对绝大多数非致病微生物区系一无所知。这种微妙的平衡的破坏会导致炎症性肠病。在这篇综述中，我们描述了我们在理解宿主-微生物区系相互作用如何塑造免疫系统以及它们如何影响对病原菌的反应方面的最新进展。
The mammalian alimentary tract harbors hundreds of species of commensal micro-organisms that intimately interact with the host immune system. Within the gut, the immune system actively reacts with potentially pathogenic microbes, while simultaneously remaining ignorant towards the vast majority of non-pathogenic microbiota. The disruption of this delicate balance results in inflammatory bowel diseases. In this review, we describe the recent advances in our understanding of how host-microbiota interactions shape the immune system and how they affect the responses against pathogenic bacteria.