Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression.
Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression.
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DOI：
10.1002/jcb.21977
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发表时间：
2009-01-01
影响因子：
4
通讯作者：
Lee, Yong J.
中科院分区：
文献类型：
--
作者：
Jeong, Jae-Hoon;An, Jee Young;Kwon, Yong Tae;Rhee, Juong G.;Lee, Yong J.
Quercetin is a flavonoid present in many vegetables, fruits and beverages. Due to its anti-oxidant, anti-tumor and anti-inflammatory activity, quercetin has been studied extensively as a chemoprevention agent in several cancer models. Since most of these studies used higher doses of quercetin than clinically achievable, we focused on the effectiveness of physiologically relevant doses of quercetin. A low dose of quercetin exerted cancer cell-specific inhibition of proliferation and this inhibition resulted from cell cycle arrest at the G1 phase. Quercetin induced p21 CDK inhibitor with a concomitant decrease of phosphorylation of pRb, which inhibits the G1/S cell cycle progression by trapping E2F1. A low dose of quercetin induced mild DNA damage and Chk2 activation, which is the main regulator of p21 expression by quercetin. In addition, quercetin down-regulated the cyclin B1 and CDK1, essential components of G2/M cell cycle progression. Inhibition of the recruitment of key transcription factor NF-Y to cyclin B1 gene promoter by quercetin led to transcriptional inhibition. This study proved that the chemopreventive efficacy of a physiologically relevant dose of quercetin can be achievable through the inhibition of cell cycle progression.
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影响因子：
64.5
作者：
ELDEIRY, WS;TOKINO, T;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
DOI：
10.1073/pnas.190030497
发表时间：
2000-09-12
影响因子：
11.1
作者：
Matsuoka, S;Rotman, G;Elledge, SJ
通讯作者：
Elledge, SJ
DOI：
10.1111/j.1432-1033.1995.tb20356.x
发表时间：
1995-01-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
PADILLA, CA;MARTINEZGALISTEO, E;HOLMGREN, A
通讯作者：
HOLMGREN, A
影响因子：
8
作者：
Beniston, RG;Campo, MS
通讯作者：
Campo, MS
DOI：
10.1073/pnas.082005599
发表时间：
2002-04-30
影响因子：
11.1
作者：
Menssen, A;Hermeking, H
通讯作者：
Hermeking, H