Targeting the tumor microenvironment: JAK-STAT3 signaling.
Targeting the tumor microenvironment: JAK-STAT3 signaling.
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DOI：
10.4161/jkst.23828
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发表时间：
2013-04-01
期刊：
影响因子：
--
通讯作者：
Bromberg J
中科院分区：
文献类型：
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作者：
Bournazou E;Bromberg J
持续的JAK-STAT3信号与肿瘤发生的许多方面有关。STAT3除了具有肿瘤内禀作用外，还具有肿瘤外禀作用，支持肿瘤存活和转移。这些包括旁分泌细胞因子信号的调节，转移部位的改变使这些转移部位允许癌细胞生长，以及破坏宿主免疫反应以创造免疫抑制环境。靶向这种信号通路被认为是一种新的有前途的治疗方法，特别是在肿瘤免疫的背景下。在本文中，我们将回顾jak - stat3靶向治疗在多大程度上影响肿瘤微环境，以及观察到的效果是否构成对治疗的反应性基础。
Persistent JAK-STAT3 signaling is implicated in many aspects of tumorigenesis. Apart from its tumor-intrinsic effects, STAT3 also exerts tumor-extrinsic effects, supporting tumor survival and metastasis. These involve the regulation of paracrine cytokine signaling, alterations in metastatic sites rendering these permissive for the growth of cancer cells and subversion of host immune responses to create an immunosuppressive environment. Targeting this signaling pathway is considered a novel promising therapeutic approach, especially in the context of tumor immunity. In this article, we will review to what extent JAK-STAT3-targeted therapies affect the tumor microenvironment and whether the observed effects underlie responsiveness to therapy.