CuSO4-catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient approach to oxindole derivatives
CuSO4-catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient approach to oxindole derivatives
复制标题
DOI：
10.1039/c2gc36708d
复制
发表时间：
2013-02
期刊：
影响因子：
9.8
通讯作者：
Changcheng Jing;Taoda Shi;D. Xing;Xin Guo;Wenhao Hu
中科院分区：
文献类型：
--
作者：
Changcheng Jing;Taoda Shi;D. Xing;Xin Guo;Wenhao Hu
研究了以CuSO 4为催化剂，α-重氮酯、水和靛红的高效三组分反应。在该反应中，水既用作反应物又用作溶剂。利用这种高度环境友好和经济的方案，以良好的产率有效地制备了一系列3-羟基吲哚啉-2-酮衍生物，具有中等至高的非对映选择性。
A highly efficient three-component reaction of α-diazo ester, water and isatin was developed by using CuSO4 as the catalyst. In this reaction, water was used as both a reactant and the solvent. With this highly environmentally benign and economical protocol, a series of 3-hydroxyindolin-2-one derivatives were efficiently produced in good yields with moderate to high diastereoselectivities.