Endoplasmic reticulum stress
Endoplasmic reticulum stress
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DOI：
10.1196/annals.1391.007
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Yang, Wei
中科院分区：
文献类型：
--
作者：
Banhegyi, Gabor;Baumeister, Peter;Yang, Wei
压力是体内平衡的不平衡，甚至可以在亚细胞水平上感受到。包括内质网（ER）在内的各种细胞器的应激感受能力已被描述。很明显，急性或长期的ER应激在许多人类疾病中起着重要作用;特别是那些涉及蛋白质分泌专门化的器官/组织的疾病。本文总结了ER应激在多种人类病理生理条件下的作用，如癌症发生和肿瘤进展，脑缺血，浆细胞成熟和凋亡，肥胖，胰岛素抵抗和2型糖尿病。ER应激反应机制的某些组分被鉴定为疾病的生物标志物或作为治疗干预的可能靶点。
Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress-sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.