Global burden of breast cancer and attributable risk factors in 195 countries and territories, from 1990 to 2017: results from the Global Burden of Disease Study 2017
Global burden of breast cancer and attributable risk factors in 195 countries and territories, from 1990 to 2017: results from the Global Burden of Disease Study 2017
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DOI：
10.1186/s13045-019-0828-0
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发表时间：
2019-12-21
影响因子：
28.5
通讯作者：
Dai, Zhijun
中科院分区：
文献类型：
--
作者：
Li, Na;Deng, Yujiao;Dai, Zhijun
研究背景乳腺癌的发病率、死亡率、疾病负担及相关危险因素的统计数据对决策具有重要价值。我们的目的是估计1990年至2017年期间按国家，性别，年龄组和社会人口状况划分的乳腺癌发病率，死亡率和残疾调整生命年（DADs）。我们从1990年至2017年的2017年全球疾病负担（GBD）研究中提取了195个国家和地区的乳腺癌数据。收集了有关乳腺癌发病病例数、死亡人数、死亡率和年龄标准化率的数据。我们还使用GBD研究的比较风险评估框架，估计了乳腺癌死亡和乳腺癌复发的风险因素。结果2017年，全球乳腺癌发病率增至1，960，681例。社会发展指数高的五分之一人口中，乳腺癌死亡人数最多。在2007年至2017年期间，全球乳腺癌的ASDR下降，特别是在高SDI和中高SDI国家。2017年，相关的残疾人为17，708，600人，其中高中SDI五分位数是最高贡献者。在大多数GBD地区，饮酒是死亡和糖尿病的最大贡献者，其他贡献者包括高体重指数（BMI）和高空腹血糖。结论全球乳腺癌负担的增加主要集中在低SDI国家;在高SDI国家，乳腺癌负担有减轻的趋势。因此，应针对归因风险因素采取措施，以减少低SDI国家的乳腺癌负担。
Background Statistical data on the incidence, mortality, and burden of breast cancer and the relevant risk factors are valuable for policy-making. We aimed to estimate breast cancer incidence, deaths, and disability-adjusted life years (DALYs) by country, gender, age group, and social-demographic status between 1990 and 2017. Methods We extracted breast cancer data from the 2017 Global Burden of Disease (GBD) study from 1990 through 2017 in 195 countries and territories. Data about the number of breast cancer incident cases, deaths, DALYs, and the age-standardized rates were collected. We also estimated the risk factors attributable to breast cancer deaths and DALYs using the comparative risk assessment framework of the GBD study. Results In 2017, the global incidence of breast cancer increased to 1,960,681 cases. The high social-development index (SDI) quintile included the highest number of breast cancer death cases. Between 2007 and 2017, the ASDR of breast cancer declined globally, especially in high SDI and high middle SDI countries. The related DALYs were 17,708,600 in 2017 with high middle SDI quintile as the highest contributor. Of the deaths and DALYs, alcohol use was the greatest contributor in most GBD regions and other contributors included high body mass index (BMI) and high fasting plasma glucose. Conclusion The increasing global breast cancer burden is mainly observed in lower SDI countries; in higher SDI countries, the breast cancer burden tends to be relieving. Therefore, steps against attributable risk factors should be taken to reduce breast cancer burden in lower SDI countries.