Immunological synapses are versatile structures enabling selective T cell polarization
Immunological synapses are versatile structures enabling selective T cell polarization
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DOI：
10.1016/j.immuni.2004.12.010
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发表时间：
2005-02-01
期刊：
影响因子：
32.4
通讯作者：
Valitutti, S
中科院分区：
文献类型：
--
作者：
Depoil, D;Zaru, R;Valitutti, S
辅助T细胞区分不同的抗原呈递细胞，以选择性的方式提供帮助。导致这种精确选择性的分子机制仍然难以捉摸。在这里，我们证明了免疫突触是动态的和适应性强的结构，允许T细胞与多个细胞通信。我们发现，T细胞可以形成同时免疫突触细胞呈现不同水平的抗原配体，但最终朝向最强的刺激。值得注意的是，活T细胞在与不同抗原呈递细胞相互作用期间形成不同强度的信号转导的离散病灶，并迅速将TCR和高尔基体朝向提供最强刺激的细胞重新定位。我们的研究结果表明，虽然T细胞激活需要持续的信号，T细胞能够快速突触重塑和迅速的极化反应。持续信号传导与优先和快速极化的组合提供了T细胞应答的高灵敏度和选择性的机制。
Helper T cells discriminate among different antigen-presenting cells to provide their help in a selective fashion. The molecular mechanisms leading to this exquisite selectivity are still elusive. Here, we demonstrate that immunological synapses are dynamic and adaptable structures allowing T cells to communicate with multiple cells. We show that T cells can form simultaneous immunological synapses with cells presenting different levels of antigenic ligands but eventually polarize toward the strongest stimulus. Remarkably, living T cells form discrete foci of signal transduction of different intensities during the interaction with different antigen-presenting cells and rapidly relocate TCR and Golgi apparatus toward the cell providing the strongest stimulus. Our results illustrate that, although T cell activation requires sustained signaling, T cells are capable of rapid synapse remodeling and swift polarization responses. The combination of sustained signaling with preferential and rapid polarization provides a mechanism for the high sensitivity and selectivity of T cell responses.