Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing
Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing
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DOI：
10.1007/s12274-020-2891-9
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发表时间：
2020-06-25
期刊：
影响因子：
9.9
通讯作者：
Zhu, Jintao
中科院分区：
文献类型：
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作者：
Du, Shuo;Zhou, Nuoya;Zhu, Jintao
伤口处理是皮肤伤口愈合的关键措施，对于维持皮肤的完整性及其功能非常重要。在伤口部位的电刺激是皮肤伤口修复的一种引人注目的策略。然而，迫切需要具有与伤口组织相当的自粘合和机械特性的可穿戴和即时护理电刺激装置。在此，我们开发了一种具有自粘性和压电纳米发电机（HPSP）的生物启发混合贴片，用于促进皮肤伤口愈合，该贴片由贻贝启发的水凝胶基质和压电纳米发电机组成，该压电纳米发电机基于对齐的静电纺丝聚（偏氟乙烯）纳米纤维。具有针对皮肤穿戴的优化模量和渗透性的装置可以自粘附到伤口部位并局部产生由运动引起的动态电压。我们发现，HPSP不仅在体外促进成纤维细胞增殖和迁移，而且在体内有效地促进胶原沉积、血管生成和再上皮化，并增加关键生长因子的表达。HPSP将全层皮肤缺损的伤口闭合时间缩短约1/3，大大加速愈合过程。这种贴片可以作为可穿戴和实时电刺激装置，在皮肤伤口愈合的临床应用中具有潜在的用途。
Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions. Electrical stimulation at the wound site is a compelling strategy for skin wound repair. However, there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue. Herein, we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator (HPSP) for promoting skin wound healing, which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride) nanofibers. The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion. We show that the HPSP not only promotes fibroblast proliferation and migrationin vitro, but also effectively facilitates the collagen deposition, angiogenesis, and re-epithelializationin vivowith the increased expressions of crucial growth factors. The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3, greatly accelerating the healing process. This patch can serve as wearable and real-time electrical stimulation devices, potentially useful in clinical applications of skin wound healing.