Verrucous carcinoma of the foot diagnosed using p53 and Ki-67 immunostaining in a patient with diabetic neuropathy
Verrucous carcinoma of the foot diagnosed using p53 and Ki-67 immunostaining in a patient with diabetic neuropathy
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使用 p53 和 Ki-67 免疫染色诊断糖尿病神经病变患者的足部疣状癌
DOI：
10.1097/dad.0000000000000117
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Masahiko Muto
中科院分区：
文献类型：
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作者：
Yoshitaka Nakamura;Keisuke Kashiwagi;Akiko Nakamura;Masahiko Muto
局部复发但无转移扩散。VC与良性病变的区别是困难的，因为表皮显示最小的血管。VSLDN最早由Gerbig和Hunziker在1995年描述。2虽然VSLDN的确切发病机制尚不清楚，但VSLDN和糖尿病溃疡都被认为是由于感觉丧失区域的慢性压力或摩擦所致。3 VC优先发生在足部，通常表现为疣状肿瘤，可能类似VSLDN。在该病例中，患者被诊断为VSLDN，右足底病变对局部治疗和清创术无反应。一个案例VC的脚发展中的慢性压力溃疡已报告。4压疮的恶性转化是罕见的，据报道发生率约为0.5%。虽然糖尿病性溃疡和VC之间的关联以前没有被证明，在这种情况下，糖尿病性溃疡在对侧足部的存在提高了VC从糖尿病性溃疡发展的可能性。据报道，p53免疫染色可用于区分VC和VSLDN，因为前者基底表皮中的p53阳性高于后者。
local recurrence but not metastatic spread. Distinguishing VC from benign lesions is difficult because the epidermis shows minimal atypia. VSLDN was first described by Gerbig and Hunziker in 1995. 2 Although the precise pathogenesis of VSLDN is unclear, both VSLDN and diabetic ulcer are thought to be due to chronic pressure or friction in an area of sensory loss. 3 VC occurs preferentially on the foot and usually appears as a warty tumor that may resemble VSLDN. In this case, the patient had been diagnosed with VSLDN, and the right sole lesion did not respond to topical treatment and debridement. A case of VC of the foot developing in a chronic pressure ulcer has been reported. 4 Malignant transformation of a pressure ulcer is rare, with a reported incidence of about 0.5%. Although an association between diabetic ulcer and VC has not been previously demonstrated, the presence of diabetic ulcer in the opposite foot in this case raised the possibility of VC developing from diabetic ulcer. It has been reported that p53 immunostaining is useful for distinguishing between VC and VSLDN because p53 positivity in the basal epidermis in the former is higher than