VALUE OF MYOGLOBIN, TROPONIN-T, AND CK-MB(MASS) IN RULING OUT AN ACUTE MYOCARDIAL-INFARCTION IN THE EMERGENCY ROOM
VALUE OF MYOGLOBIN, TROPONIN-T, AND CK-MB(MASS) IN RULING OUT AN ACUTE MYOCARDIAL-INFARCTION IN THE EMERGENCY ROOM
复制标题
DOI：
10.1161/01.cir.92.12.3401
复制
发表时间：
1995-12-15
期刊：
影响因子：
37.8
通讯作者：
SANDERS, GT
中科院分区：
文献类型：
--
作者：
DEWINTER, RJ;KOSTER, RW;SANDERS, GT
背景排除急性心肌梗死（AMI）的基础上，快速检测心脏标志物将允许早期分诊的患者和成本效益的使用现有的冠状动脉护理facility.Methods和结果我们研究了肌红蛋白，肌酸激酶（CK）-MB（质量）和肌钙蛋白T的价值，排除急性心肌梗死在急诊室在309例连续胸痛患者。AMI的金标准是病史、ECG和CK-MB活性（CK-MB（act））的典型曲线的组合。肌红蛋白是最早的标志物，其阴性预测值（NPV）在症状发作后3 - 6小时显著高于CK-MB（mass）和肌钙蛋白T（肌红蛋白vs CKMB（mass）P
Background Ruling out acute myocardial infarction (AMI) on the basis of rapid assays for cardiac markers will allow early triage of patients and cost-effective use of available coronary care facilities.Methods and Results We studied the value of myoglobin, creatine kinase (CK)-MB(mass) and troponin T in ruling out an AMI in the emergency room in 309 consecutive patients presenting with chest pain. The gold standard for AMI was the combination of history, EGG, and a typical curve of the CK-MB activity (CK-MB(act)). Myoglobin was the earliest marker, and its negative predictive value (NPV) was significantly higher than for CK-MB(mass) and troponin T from 3 to 6 hours after the onset of symptoms (myoglobin versus CKMB(mass) P