Neuropathological Changes in Nakalanga Syndrome-A Case Report.
Neuropathological Changes in Nakalanga Syndrome-A Case Report.
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DOI：
10.3390/pathogens10020116
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发表时间：
2021-01-23
期刊：
影响因子：
--
通讯作者：
Colebunders R
中科院分区：
文献类型：
--
作者：
Hotterbeekx A;Lammens M;Onzivua S;Lukande R;Olwa F;Kumar-Singh S;Van Hees S;Idro R;Colebunders R
纳卡兰加综合征是盘尾丝虫病相关癫痫的一种临床表现，其特征是发育迟缓、第二性发育迟缓或缺失以及骨骼畸形，常伴有癫痫发作。纳卡兰加综合征的病理生理学尚不清楚。在这里，我们描述了乌干达北部一名死于纳卡兰加综合征的 17 岁女性的尸检结果。对所有主要器官（肝、肺、肾和心脏），包括大脑和垂体进行宏观和组织病理学检查。疑似死亡原因是疟疾，除了肺部出现与疟疾一致的水肿外，所有主要器官和脑下垂体均显示正常。神经病理学变化包括神经炎症迹象（神经胶质增生和活化的小胶质细胞），其与 tau 反应性神经原纤维缠结和线共存。病理在额叶皮层、丘脑和下丘脑区域以及中脑中最为丰富。脉络丛可见砂粒体。这些发现表明衰老加速，可能是由于反复癫痫发作所致。神经病理学结果与其他死于盘尾丝虫病相关癫痫的人相似。垂体检查没有揭示有关纳卡兰加综合征潜在病理生理机制的新信息。因此，应该进行更多的尸检研究。
Nakalanga syndrome is a clinical manifestation of onchocerciasis-associated epilepsy characterized by stunting, delayed or absent secondary sexual development and skeletal deformities, and is often accompanied by epileptic seizures. The pathophysiology of Nakalanga syndrome is unknown. Here, we describe the post-mortem findings of a 17-year-old female who died with Nakalanga syndrome in northern Uganda. Macroscopic and histopathological examination of all major organs (liver, lungs, kidney and heart), including the brain and the pituitary gland, was performed. The suspected cause of death was malaria, and all major organs and pituitary gland appeared normal, except the lungs, which were edematous consistent with the malaria. Neuropathological changes include signs of neuro-inflammation (gliosis and activated microglia), which co-localized with tau-reactive neurofibrillary tangles and threads. The pathology was most abundant in the frontal cortex, thalamic and hypothalamic regions, and mesencephalon. The choroid plexus showed psammoma bodies. These findings indicate accelerated aging, probably due to repeated seizures. The neuropathological findings were similar to other persons who died with onchocerciasis-associated epilepsy. Examination of the pituitary gland did not reveal new information concerning the underlying pathophysiological mechanism of Nakalanga syndrome. Therefore, more post-mortem studies should be performed.
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磷酸化的tau是慢性创伤性脑病所独有的吗？癫痫大脑和慢性创伤性脑病中的磷酸化tau。
影响因子：
2.9
作者：
Puvenna V;Engeler M;Banjara M;Brennan C;Schreiber P;Dadas A;Bahrami A;Solanki J;Bandyopadhyay A;Morris JK;Bernick C;Ghosh C;Rapp E;Bazarian JJ;Janigro D
通讯作者：
Janigro D
影响因子：
1
作者：
Tumwine, J. K.;Vandemaele, K.;Spencer, P. S.
通讯作者：
Spencer, P. S.
影响因子：
2.6
作者：
Siewe, Joseph F. N.;Ngarka, Leonard;Njamnshi, Alfred K.
通讯作者：
Njamnshi, Alfred K.
DOI：
10.1016/0035-9203(61)90024-4
发表时间：
1961-01-01
期刊：
TRANS ROY SOC TROP MED AND HYG
影响因子：
--
作者：
MARSHALL, A. J.;CHERRY, J. K. T.
通讯作者：
CHERRY, J. K. T.
影响因子：
2.3
作者：
Bhwana, Dan;Mmbando, Bruno P.;Colebunders, Robert
通讯作者：
Colebunders, Robert