DNA-controlled aggregation of virus like particles – mimicking a tetherin-like mechanism
DNA-controlled aggregation of virus like particles – mimicking a tetherin-like mechanism
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DOI：
10.1039/c4nj00724g
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发表时间：
2014-10
影响因子：
3.3
通讯作者：
D. Serien;C. Grimm;J. Liebscher;A. Herrmann;A. Arbuzova
中科院分区：
文献类型：
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作者：
D. Serien;C. Grimm;J. Liebscher;A. Herrmann;A. Arbuzova
通过功能相似的结构来模拟细胞过程有助于理解它们的分子机制。我们报告了一种用两个α-生育酚锚修饰的寡核苷酸，模拟tetherin，一种减少病毒传播的细胞蛋白。亲脂性DNA被掺入囊泡和病毒样颗粒中;它们的聚集由补体添加诱导。
Mimicking cellular processes by functional comparable structures helps to understand their molecular mechanism. We report on an oligonucleotide modified with two α-tocopherol anchors mimicking tetherin, a cellular protein reducing spreading of viruses. The lipophilic DNA was incorporated into vesicles and virus like particles; their aggregation was induced by the complement addition.