ACTIVATION OF SEXUAL REFLEXES IN MALE RATS BY SPINAL IMPLANTATION OF TESTOSTERONE
ACTIVATION OF SEXUAL REFLEXES IN MALE RATS BY SPINAL IMPLANTATION OF TESTOSTERONE
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DOI：
10.1016/0031-9384(68)90144-3
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发表时间：
1968-01-01
影响因子：
2.9
通讯作者：
HAUGEN, CM
中科院分区：
文献类型：
--
作者：
HART, BL;HAUGEN, CM
以前曾报道，外源性睾酮的全身给药和停药对去势脊髓雄性大鼠的性反射有定量影响。在本研究中，试图确定这种影响是否发生在性反射的外围或中心元素。去势的雄性大鼠的性反射活动水平较低，接受丙酸睾酮或胆固醇的脊柱植入。检查附属性腺以控制植入雄激素吸收进入体循环，显示雄激素吸收证据的受试者被排除在进一步考虑之外。植入替吉奥的受试者表现出性反射活动的增加，而植入胆固醇的受试者表现出性反射活动的下降。结果表明，睾酮通过直接作用于介导性反射的脊髓神经组织，对性反射有促进作用。
It has been previously reported that the systemic administration and withdrawal of exogenous testosterone has a quantitative influence on sexual reflexes of castrated spinal male rats. In the present study an attempt was made to determine whether this effect occurred in the peripheral or central elements of the sexual reflexes. Castrated spinal male rats that had a low level of sexual reflex activity received spinal implants of either testosterone propionate or cholesterol. The accessory sex glands were examined to control for absorption of the implanted androgen into the systemic circulation, and subjects which showed such evidence of absorption of the androgen were excluded from further consideration. Testosterone implanted subjects exhibited an increase in sexual reflex activity, whereas cholesterol implanted subjects showed a decline in sexual reflex activity. The results suggest that testosterone has a facilitory influence on sexual reflexes by means of a direct action on spinal neural tissue mediating sexual reflexes.