Synthesis of substituted 1-tetralones
Synthesis of substituted 1-tetralones
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DOI：
10.1080/00304949709355222
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发表时间：
1997-08-01
影响因子：
1.5
通讯作者：
Kumar, P
中科院分区：
文献类型：
--
作者：
Kumar, P
第29卷，第4期，1997 OPPI BRIEFS 50 psi，然后水解得到酸8。在室温下，用多磷酸酯（PPE）在CHCl中处理化合物8，得到2（77.8%总产率），沿着得到8-甲氧基-四氢萘酮（9）（8%）。类似地，将苄基氯（10）转化为1-四氢萘酮（3）（总产率77%）。以2，3-二甲氧基苄基氯（11当量）为起始原料，用上述方法合成了5，6-二甲氧基-1-四氢萘酮（4）（总收率67%）。
Volume 29, No. 4, 1997 OPPI BRIEFS50 psi followed by hydrolysis gave the acid 8. Compound 8 was treated with polyphosphoric ester (PPE)'in CHCl, at room temperature to give 2 (77.8% overall yield) along with 8-methoxy-ltetralone (9)(8%). Similarly, benzyl chloride (10) was converted into 1-tetralone (3)(overall yield 77%). The synthesis of 5, 6-dimethoxy-1-tetralone (4)(overall yield 67%) was also completed by the above approach starting from 2, 3-dimethoxybenzyl chloride (11)'.